{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T14:58:16Z","timestamp":1790780296317,"version":"4.1.0"},"reference-count":125,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82401943"],"award-info":[{"award-number":["82401943"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000011","name":"Howard Hughes Medical Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000011","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioEssays"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>A complex network of protein interactions promotes the cooperative assembly of biomolecular condensates that control the formation of meiotic DNA double\u2010strand breaks (DSBs). In many species, programmed DSBs made by SPO11 are required for the faithful pairing and segregation of homologous chromosomes during meiosis I. DSBs must be tightly regulated to support their intended function but also to minimize the risk of genomic damage from mutation or defective DSB repair. Multiple chromosome axis\u2010associated proteins are important for the control of meiotic DSB formation and recombination, but the underlying mechanisms of those proteins remain poorly understood. Here, we present a current view of how these proteins work together in mice, based on recent advances in the characterization of their function and structure.<\/jats:p>","DOI":"10.1002\/bies.70190","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T14:22:11Z","timestamp":1790778131000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Controlling Meiotic Double\u2010Strand Break Formation in Mice: A Web of Multivalent Protein\u2013Protein Interactions"],"prefix":"10.1002","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-6348-3769","authenticated-orcid":false,"given":"Jiaqi","family":"Xu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Department of Obstetrics and Gynecology Peking University Third Hospital  Beijing China"},{"name":"Weill Cornell Graduate School of Medical Sciences  New York New York USA"},{"name":"Molecular Biology Program Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1283-6417","authenticated-orcid":false,"given":"Scott","family":"Keeney","sequence":"additional","affiliation":[{"name":"Weill Cornell Graduate School of Medical Sciences  New York New York USA"},{"name":"Molecular Biology Program Memorial Sloan Kettering Cancer Center  New York New York USA"},{"name":"Howard Hughes Medical Institute Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,30]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1086605"},{"key":"e_1_2_11_3_1","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1146\/annurev-genet-110711-155423","article-title":"Initiation of Meiotic Recombination: How and Where? Conservation and Specificities Among Eukaryotes","volume":"47","author":"Massy B.","year":"2013","journal-title":"Annual Review of Genetics"},{"key":"e_1_2_11_4_1","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a016634","article-title":"Mechanism and Regulation of Meiotic Recombination Initiation","volume":"7","author":"Lam I.","year":"2015","journal-title":"Cold Spring Harbor Perspectives in Biology"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742\u20104658.2009.07502.x"},{"key":"e_1_2_11_6_1","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a016618","article-title":"Meiotic Recombination: The Essence of Heredity","volume":"7","author":"Hunter N.","year":"2015","journal-title":"Cold Spring Harbor Perspectives in Biology"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.16.8167"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a016626"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2006.03.009"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg3245"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2849"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.642737"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.20.7218"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.203001"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1159\/000330627"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749\u20106632.2012.06593.x"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1530\/rep.0.1210655"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1195774"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.09.035"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.10.5213"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.02.009"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1183439"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1182363"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1007479"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11089"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2018.01.033"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.57117"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.333542.119"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2024.04.001"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41576\u2010023\u201000669\u20108"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.864101"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.0030191"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dnarep.2025.103886"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00412\u2010010\u20100274\u20109"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aad5309"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41594\u2010024\u201001382\u20108"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010025\u201008601\u20102"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010024\u201008551\u20101"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010024\u201008574\u20108"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aad5196"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.26508\/lsa.201800259"},{"key":"e_1_2_11_42_1","first-page":"1800","article-title":"MEI4 \u2013 a Central Player in the Regulation of Meiotic DNA Double\u2010Strand Break Formation in the Mouse","volume":"128","author":"Kumar R.","year":"2015","journal-title":"Journal of Cell Science"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb3417"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102443.2006.00972.x"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2432067100"},{"key":"e_1_2_11_46_1","doi-asserted-by":"crossref","first-page":"4126","DOI":"10.1038\/sj.emboj.7601815","article-title":"AtPRD1 is Required for Meiotic Double Strand Break Formation in Arabidopsis thaliana","volume":"26","author":"De Muyt A.","year":"2007","journal-title":"EMBO Journal"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2019.03.023"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2019.03.022"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/bies.950090503"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.genet.33.1.603"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00412\u2010006\u20100055\u20107"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e08\u201012\u20101223"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.07.003"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092\u20108674(02)01167\u20104"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/gtc.12138"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092\u20108674(00)80609\u20101"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092\u20108674(90)90216\u20102"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.136.5.957"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2009.08.007"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.00495"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200603063"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1097\u20102765(00)80404\u20109"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/16.17.5207"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.147.2.207"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm.2017.7"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaf4382"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10879"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2018.02.004"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010021\u201003374\u2010w"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010024\u201047020\u20101"},{"key":"e_1_2_11_71_1","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkaf123","article-title":"Mug20\u2010Rec25\u2010Rec27 Binds DNA and Enhances Meiotic DNA Break Formation via Phase\u2010Separated Condensates","volume":"53","author":"Wang M. F.","year":"2025","journal-title":"Nucleic Acids Research"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.350461.123"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00412\u2010007\u20100111\u2010y"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2012.11.008"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1225739"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00412\u2010017\u20100631\u2010z"},{"key":"e_1_2_11_77_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010020\u20102327\u20104"},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.1038\/386414a0"},{"key":"e_1_2_11_79_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/26.22.5157"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M101823200"},{"key":"e_1_2_11_81_1","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb1264"},{"key":"e_1_2_11_82_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010026\u201069491\u20100"},{"key":"e_1_2_11_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092\u20108674(00)81876\u20100"},{"key":"e_1_2_11_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0070\u20102153(01)52008\u20106"},{"key":"e_1_2_11_85_1","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1999.5956"},{"key":"e_1_2_11_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1097\u20102765(00)00097\u20106"},{"key":"e_1_2_11_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2016.02.025"},{"key":"e_1_2_11_88_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abm4805"},{"key":"e_1_2_11_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0968\u20100004(99)01503\u20100"},{"key":"e_1_2_11_90_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkae587"},{"key":"e_1_2_11_91_1","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msac227"},{"key":"e_1_2_11_92_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010022\u201034799\u20100"},{"key":"e_1_2_11_93_1","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1999.5955"},{"key":"e_1_2_11_94_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature03872"},{"key":"e_1_2_11_95_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00002\u201010"},{"key":"e_1_2_11_96_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018\u2010023\u201004912\u20107"},{"key":"e_1_2_11_97_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/18.21.6177"},{"key":"e_1_2_11_98_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkl1162"},{"key":"e_1_2_11_99_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010021\u201003389\u20103"},{"key":"e_1_2_11_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.10.025"},{"key":"e_1_2_11_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.04.039"},{"key":"e_1_2_11_102_1","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.106.058768"},{"key":"e_1_2_11_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1097\u20102765(04)00063\u20102"},{"key":"e_1_2_11_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2012.06.023"},{"key":"e_1_2_11_105_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.72330"},{"key":"e_1_2_11_106_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.350462.123"},{"issue":"15","key":"e_1_2_11_107_1","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkag785","article-title":"Insights Into the Recruitment of the H3K4me3 Reader Spp1 by the Meiotic Double\u2010Strand Break Protein Mer2","volume":"54","author":"Liloku P.","year":"2026","journal-title":"Nucleic Acids Research"},{"key":"e_1_2_11_108_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.571710"},{"key":"e_1_2_11_109_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.304543.117"},{"key":"e_1_2_11_110_1","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2023113866"},{"key":"e_1_2_11_111_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2310951120"},{"key":"e_1_2_11_112_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41594\u2010020\u201000534\u2010w"},{"key":"e_1_2_11_113_1","first-page":"129","article-title":"Structure and Chromosomal Mapping of a Highly Polymorphic Repetitive DNA Sequence From the Pseudoautosomal Region of the Mouse Sex Chromosomes","volume":"53","author":"Harbers K.","year":"1990","journal-title":"Cytogenetics and Cell Genetics"},{"key":"e_1_2_11_114_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00337383"},{"key":"e_1_2_11_115_1","doi-asserted-by":"crossref","unstructured":"T.Kasahara K.Mekada K.Abe A.Ashworth andT.Kato \u201cComplete Sequencing of the Mouse Pseudoautosomal Region the Most Rapidly Evolving \u2018Chromosome\u2019 \u201d preprint bioRxiv March 27 2022 https:\/\/doi.org\/10.1101\/2022.03.26.485930.","DOI":"10.1101\/2022.03.26.485930"},{"key":"e_1_2_11_116_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2213"},{"key":"e_1_2_11_117_1","doi-asserted-by":"publisher","DOI":"10.1159\/000443157"},{"key":"e_1_2_11_118_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1626408"},{"key":"e_1_2_11_119_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1626608"},{"key":"e_1_2_11_120_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1003545"},{"key":"e_1_2_11_121_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7600184"},{"key":"e_1_2_11_122_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.57720"},{"key":"e_1_2_11_123_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10508"},{"key":"e_1_2_11_124_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201104121"},{"key":"e_1_2_11_125_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1117937108"},{"key":"e_1_2_11_126_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1801920115"}],"container-title":["BioEssays"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bies.70190","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/bies.70190","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bies.70190","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T14:22:14Z","timestamp":1790778134000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/bies.70190"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,30]]},"references-count":125,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/bies.70190"],"URL":"https:\/\/doi.org\/10.1002\/bies.70190","archive":["Portico"],"relation":{},"ISSN":["0265-9247","1521-1878"],"issn-type":[{"value":"0265-9247","type":"print"},{"value":"1521-1878","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,30]]},"assertion":[{"value":"2025-12-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70190"}}