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Microtubules act as tracks for motor protein\u2010driven intracellular transport of organelles, vesicles, and macromolecules; therefore, their structural organization and stability are important. Kinesin and dynein motor proteins function not only as cargo transporters but also as contributors to the regulation of microtubule organization, stability, and interactions. The interaction of motor proteins and microtubules is essential for cellular homeostasis, and dysregulations can affect motility\u2010dependent cellular processes such as intracellular trafficking and cell division. 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