{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T15:50:06Z","timestamp":1791561006304,"version":"4.3.4"},"reference-count":76,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:00:00Z","timestamp":1791504000000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["HORIZON\u2010CL6\u20102021\u2010UE101060625"],"award-info":[{"award-number":["HORIZON\u2010CL6\u20102021\u2010UE101060625"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioEssays"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The prevailing view of biological evolution is not unlike bricolage\/pastiche\/tinkering\u2014in sharp contrast with rational engineering. Yet, different paths often lead to solutions that coincide or converge whether they emerge from naturally\u2010occurring evolution or rationally designed. Such a conjunction\u2014often presented as an anecdote\u2014reveals the ability of biological systems to explore solution spaces and gravitate toward information\u2010rich attractors, which can be found through different routes. This scenario evokes one of embodied computing, a non\u2010conventional type of data processing in which the solution to a problem is not delivered through numerical calculations but through its implementation in a material object. Once left to undergo a physical process the object manages a large number of parameters for reaching a multi objective optimum through thermodynamically\u2010driven processes. The course of information is thus a physical flow and the outcome is a physical currency. The consequences of this notion for bioengineering are remarkable.<\/jats:p>","DOI":"10.1002\/bies.70196","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T15:04:20Z","timestamp":1791558260000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Biological Systems as Physical Data Processors: Evolution\u00a0as\u00a0a\u00a0Case of Embodied Computing"],"prefix":"10.1002","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6041-2731","authenticated-orcid":false,"given":"V\u00edctor","family":"de Lorenzo","sequence":"first","affiliation":[{"name":"Systems Biology Department Centro Nacional de Biotecnolog\u00eda CSIC  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,9]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00142899"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.2003243"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature04342"},{"key":"e_1_2_14_5_1","doi-asserted-by":"crossref","DOI":"10.7208\/chicago\/9780226826691.001.0001","volume-title":"How Life Works","author":"Ball P.","year":"2023"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/509155a"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/463288a"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41587\u2010019\u20100171\u20106"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkz745"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aav5477"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.15252\/msb.20209584"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymben.2019.08.004"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41589\u2010020\u20100532\u2010y"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/acssynbio.0c00135"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41587\u2010019\u20100157\u20104"},{"key":"e_1_2_14_16_1","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s40504-018-0086-x","article-title":"Evolutionary Tinkering vs. rational Engineering in the Times of Synthetic Biology","volume":"14","author":"Lorenzo V.","year":"2018","journal-title":"Life Sciences, Society and Policy"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2011220117"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010024\u201048000\u20101"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1162\/106365602760234108"},{"key":"e_1_2_14_20_1","volume-title":"Advances in Computer Architecture","author":"Myers G. 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