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Evolutionary relationships between the genes of different species are discussed, as well as the regulatory mechanisms that in both laboratory mutants and clinical isolates lead to overproduction of \u03b2\u2010lactamase.<\/jats:p>","DOI":"10.1002\/bies.950030107","type":"journal-article","created":{"date-parts":[[2005,2,25]],"date-time":"2005-02-25T12:06:03Z","timestamp":1109333163000},"page":"22-26","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Evolution of resistance to penicillin and cephalosporin antibiotics"],"prefix":"10.1002","volume":"3","author":[{"given":"Staffan","family":"Normark","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederik","family":"Lindberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,2,5]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.52.070183.004141"},{"key":"e_1_2_1_3_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/mr.49.1.1-32.1985","article-title":"Molecular basis of outer membrane permeability","volume":"49","author":"Nikaido H.","year":"1985","journal-title":"Microbiol. 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