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The structural similarities between the neuropeptide CGRP and IAPP support the premise that IAPP is hormonal in nature. Our immunohistochemical studies also indicate that normal islet B\u2010cells of several mammalian species (including man and cat) give strong immunoreactivity with antiserum directed to a synthetic peptide segment of IAPP. The fact that IAPP is deposited as amyloid in the pancreatic islets of type 2 (noninsulin\u2010dependent) diabetics strongly supports an important but yet unknown link between IAPP and the development of this disease.<\/jats:p>","DOI":"10.1002\/bies.950090109","type":"journal-article","created":{"date-parts":[[2005,2,25]],"date-time":"2005-02-25T08:47:53Z","timestamp":1109321273000},"page":"30-33","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["The pathogenesis of maturity\u2010onset diabetes mellitus: Is there a link to islet amyloid polypeptide?"],"prefix":"10.1002","volume":"9","author":[{"given":"Per","family":"Westermark","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth H.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,2,5]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.5.4.397"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198006053022305"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/030098588101800303"},{"key":"e_1_2_1_5_2","first-page":"291","article-title":"The pancreatic islet cells in insular amyloidosis in human diabetic and non\u2010diabetic adults","volume":"81","author":"Westermark P.","year":"1973","journal-title":"Acta Path. 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