{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T04:05:46Z","timestamp":1791173146494,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,2,5]],"date-time":"2005-02-05T00:00:00Z","timestamp":1107561600000},"content-version":"vor","delay-in-days":5059,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioEssays"],"published-print":{"date-parts":[[1991,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Sex determination in mammals is mediated <jats:italic>via<\/jats:italic> the supporting cell lineage in the fetal gonad. In the very early stages of gonadal development, the fate of the supporting cell population is critically dependent on the expression of the male\u2010determining gene on the Y chromosome. If this gene is absent or fails to be expressed, or is expressed too late or in too small a number of supporting cells, all supporting cells (XX or XY) differentiate as pre\u2010follicle cells and development proceeds along the female pathway. Supporting cells in which the male\u2010determining gene is expressed in a timely manner differentiate as pre\u2010Sertoli cells; given sufficient such cells, testis cords form and development proceeds in a male direction. If XX supporting cells are also present, a few may be recruited into the pre\u2010Sertoli population and participate in testis cord formation. The subsequent fate of pre\u2010follicle cells depends critically on interaction with the germ cell population in the developing gonad: absence of germ cells may lead to partial masculinization of the gonad, and\/or to disappearance of the supporting cell component.<\/jats:p>","DOI":"10.1002\/bies.950130402","type":"journal-article","created":{"date-parts":[[2005,2,25]],"date-time":"2005-02-25T11:15:04Z","timestamp":1109330104000},"page":"151-156","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":165,"title":["Development of the mammalian gonad: The fate of the supporting cell lineage"],"prefix":"10.1002","volume":"13","author":[{"given":"Anne","family":"McLaren","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,2,5]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.110.2.521"},{"key":"e_1_2_1_3_2","unstructured":"Buehr M.andMcLaren A.(1991).Mesonephric contribution to testis differentiation in the fetal mouse in preparation."},{"key":"e_1_2_1_4_2","first-page":"18","volume-title":"Development and Function of the Reproductive Organs","author":"Upadhyay S.","year":"1981"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/jez.1402360213"},{"key":"e_1_2_1_6_2","first-page":"171","volume-title":"Progress in Developmental Biology","author":"Taketo T.","year":"1986"},{"key":"e_1_2_1_7_2","first-page":"1","article-title":"Studies on sex differentiation in mammals","volume":"29","author":"Jost A.","year":"1973","journal-title":"Rec. 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