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Such a system was identified in a series of radiation\u2010induced chromosomal deletions at and around the albino (<jats:italic>c<\/jats:italic>) locus of the mouse associated with cell type\u2010specific effects on liver differentiation. Their detailed study has aided the analysis of possible machanisms of cell type\u2010specific gene expression. As summarized in this review, the experimental results strongly suggest that specific <jats:italic>trans<\/jats:italic>\u2010acting developmental regulatory genes are concerned with the differentiation of hormone\u2010inducible expression of a cluster of hepatocyte specific structural genes mapping in different parts of the genome.<\/jats:p>","DOI":"10.1002\/bies.950131102","type":"journal-article","created":{"date-parts":[[2005,2,25]],"date-time":"2005-02-25T10:32:16Z","timestamp":1109327536000},"page":"557-561","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Lethal chromosomal deletions in the mouse, a model system for the study of development and regulation of postnatal gene expression"],"prefix":"10.1002","volume":"13","author":[{"given":"Salome","family":"Gluecksohn\u2010Waelsch","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donald","family":"Defranco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,2,5]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-9525(88)80003-9"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(89)90912-4"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0168-9525(89)90029-2"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.59.2.437"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.58.3.549"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00292845"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(79)90001-1"},{"key":"e_1_2_1_9_2","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1093\/genetics\/100.3.427","article-title":"Analysis of the albino\u2010locus regions of the mouse: IV. 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