{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,21]],"date-time":"2025-06-21T04:28:35Z","timestamp":1750480115554},"reference-count":64,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2005,2,5]],"date-time":"2005-02-05T00:00:00Z","timestamp":1107561600000},"content-version":"vor","delay-in-days":4845,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioEssays"],"published-print":{"date-parts":[[1991,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We desperately need to know more of the biological details of the onset and progression of breast cancer. The disease is of startlingly high incidence (approaching 1 in 9 women), our current therapies for the disease are inadequate once it has metastasized, and the disease is characterized by excessive morbidity and mortality.<\/jats:p><jats:p>Most of the growth and differentiation of the mammary gland occurs relatively late in life: during sexual maturation, and then cyclically during pregnancy and lactation. Normal as well as malignant growth is regulated by endocrine hormones as well as by local tissue factors, such as polypeptide growth factors, Cancer seems to progress as hyperplastic ductal or lobular epithelial growth, acquiring progressive genetic changes (including those of oncogenes and tumor suppressor genes) leading to clonal outgrowths of progressively more malignant cells. The nature of proliferative controls and the relevant genetic changes are the subjects of the current review.<\/jats:p>","DOI":"10.1002\/bies.950131109","type":"journal-article","created":{"date-parts":[[2005,2,25]],"date-time":"2005-02-25T10:32:16Z","timestamp":1109327536000},"page":"591-596","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Molecular insights into breast cancer from transgenic mouse models"],"prefix":"10.1002","volume":"13","author":[{"given":"Robert B.","family":"Dickson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Macro M.","family":"Gottardis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Glenn T.","family":"Merlino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,2,5]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"235","volume-title":"The Breast","author":"Mant D.","year":"1991"},{"key":"e_1_2_1_3_2","first-page":"3415","article-title":"Host factors affecting the growth of carcinogen\u2010induced rat mammary carcinomas: a review and tribute to Charles Brenton Huggins","volume":"45","author":"Welsch C. W.","year":"1985","journal-title":"Cancer Res."},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0277-5379(93)90019-2"},{"key":"e_1_2_1_5_2","first-page":"2203","article-title":"Mechanisms of tumor progression","volume":"46","author":"Nowell P. C.","year":"1986","journal-title":"Cancer Res."},{"key":"e_1_2_1_6_2","first-page":"900","volume-title":"The Breast","author":"Witliff J. D.","year":"1991"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.94.3.403"},{"key":"e_1_2_1_8_2","first-page":"1355","article-title":"Augmentation of the response of normal mammary epithelial cells to estradiol by mammary stroma","volume":"43","author":"McGrath C. M.","year":"1983","journal-title":"Cancer Res."},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1041450204"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1210\/mend-4-7-1041"},{"key":"e_1_2_1_11_2","first-page":"305","volume-title":"Regulation of Breast Cancer","author":"Musgrove E. A.","year":"1990"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1210\/mend-2-6-543"},{"key":"e_1_2_1_13_2","first-page":"4555","article-title":"Epidermal growth factor gene expression in human breast cancer cells: regulation of expression by progestins","volume":"48","author":"Murphy L. C.","year":"1988","journal-title":"Cancer Res."},{"key":"e_1_2_1_14_2","first-page":"728","article-title":"Progestin regulation of epidermal growth factor receptor in Human mammary carcinoma cells","volume":"46","author":"Murphy L. J.","year":"1986","journal-title":"Mol. Endocrinol."},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(87)90193-0"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(90)90059-R"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4613-1733-3_12"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4613-1733-3_17"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.3474783"},{"key":"e_1_2_1_20_2","first-page":"145","article-title":"Epidermal growth factor receptor, platelet\u2010derived growth factor receptor and c\u2010erbB2 receptor activation all promote growth but have distinctive effects upon mammary epithelial cell differentiation","volume":"2","author":"Taverna D.","year":"1991","journal-title":"Cell Growth and Differentiation"},{"key":"e_1_2_1_21_2","unstructured":"Grosse R.(1990).Polypeptide growth factors for the development of mammary epithelium. J. Cancer Research and Clinical Oncology. Supplement (part II) to Vol. 116 p.886."},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.81.17.5435"},{"key":"e_1_2_1_23_2","first-page":"401","volume-title":"Regulation of Breast Cancer","author":"Haslam S. Z.","year":"1990"},{"key":"e_1_2_1_24_2","first-page":"93","volume-title":"Regulation of Breast Cancer","author":"Yee D.","year":"1990"},{"key":"e_1_2_1_25_2","unstructured":"Cullen K. J. Hill S. Paik S. Smith H. S. Lippman M.andRosen N.(1990). Growth factor mRNA expression by human breast fibroblasts from benign and malignant lesions.Proc. Am. Assoc. Cancer Res. (abstr.)."},{"key":"e_1_2_1_26_2","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1091\/mbc.1.11.863","article-title":"Neoplastic transformation of mouse mammary epithelial cells by deregulated myc expression","volume":"1","author":"Telang N. J.","year":"1990","journal-title":"Cell Regulation"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.13.4834"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.2470152"},{"key":"e_1_2_1_29_2","first-page":"1398","article-title":"Epidermal\u2010growth\u2010factor receptor status as predictor of early recurrence of and death from breast cancer","author":"Sainsbury J. R.","year":"1987","journal-title":"Lancet"},{"key":"e_1_2_1_30_2","first-page":"112","article-title":"Biological and molecular bases of mammary carcinogenesis","volume":"57","author":"Russo J.","year":"1987","journal-title":"Lab. Invest."},{"key":"e_1_2_1_31_2","first-page":"283","volume-title":"The activation of cellular oncogenes by proviral insertion in murine mammary cancer. In Breast Cancer: Cellular and Molecular Biology","author":"Nusse R.","year":"1988"},{"key":"e_1_2_1_32_2","first-page":"463","article-title":"The mouse int\u20102 gene exhibits basic fibroblast growth factor activity in a basic fibroblast growth factor\u2010responsive cell line","volume":"1","author":"Merlo G.","year":"1990","journal-title":"Cell Growth and Differentiation"},{"key":"e_1_2_1_33_2","first-page":"23","volume-title":"Regulation of Breast Cancer","author":"Lee E.","year":"1990"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/342705a0"},{"key":"e_1_2_1_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/0168-9525(90)90181-5"},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1978757"},{"key":"e_1_2_1_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/348747a0"},{"key":"e_1_2_1_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/0968-0004(90)90162-5"},{"key":"e_1_2_1_39_2","first-page":"6550","article-title":"Altered expression of Nm23, a gene associated with low tumor metastatic potential, during adenovirus 2E1a inhibition of experimental metastases","volume":"48","author":"Steeg P. S.","year":"1988","journal-title":"Cancer Res."},{"key":"e_1_2_1_40_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.2662405"},{"key":"e_1_2_1_41_2","doi-asserted-by":"crossref","first-page":"15137","DOI":"10.1016\/S0021-9258(18)48149-5","article-title":"Identification of a polypeptide growth inhibitor from bovine mammary gland","volume":"262","author":"Bohmer F. D.","year":"1987","journal-title":"J. Biol. Chem."},{"key":"e_1_2_1_42_2","first-page":"299","article-title":"Differential regulation of three transforming growth factor \u03b2 species in human breast cancer cell lines by estradiol","volume":"50","author":"Arrick B. A.","year":"1990","journal-title":"Cancer Res."},{"key":"e_1_2_1_43_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.2218496"},{"key":"e_1_2_1_44_2","first-page":"363","volume-title":"In The Breast","author":"Dickson R. B.","year":"1990"},{"key":"e_1_2_1_45_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI112580"},{"key":"e_1_2_1_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(84)90257-5"},{"key":"e_1_2_1_47_2","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1002\/j.1460-2075.1988.tb02797.x","article-title":"Targeted c\u2010myc gene expression in mamary glands of transgenic mice induces mammary tumors with constitutive milk protein gene transcription","volume":"7","author":"Schonenberger C. A.","year":"1988","journal-title":"EMBO J."},{"key":"e_1_2_1_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(87)90449-1"},{"key":"e_1_2_1_49_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.9.2.854"},{"key":"e_1_2_1_50_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.5.1299"},{"key":"e_1_2_1_51_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.2.11.1486"},{"key":"e_1_2_1_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(88)90184-5"},{"key":"e_1_2_1_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(89)90331-0"},{"key":"e_1_2_1_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(90)90077-R"},{"key":"e_1_2_1_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(90)90076-Q"},{"key":"e_1_2_1_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(90)90075-P"},{"key":"e_1_2_1_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(90)90267-M"},{"key":"e_1_2_1_58_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo-128-1-539"},{"key":"e_1_2_1_59_2","first-page":"262","volume-title":"The Breast","author":"Lynch H. T.","year":"1991"},{"key":"e_1_2_1_60_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.2270486"},{"key":"e_1_2_1_61_2","doi-asserted-by":"publisher","DOI":"10.1038\/336577a0"},{"key":"e_1_2_1_62_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198705213162101"},{"key":"e_1_2_1_63_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.2270482"},{"key":"e_1_2_1_64_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.2204108"},{"key":"e_1_2_1_65_2","first-page":"7415","article-title":"Increased cell division as a cause of human cancer","volume":"50","author":"Preston\u2010Martin S.","year":"1990","journal-title":"Cancer Res."}],"container-title":["BioEssays"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbies.950131109","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bies.950131109","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T06:28:04Z","timestamp":1698042484000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/bies.950131109"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,11]]},"references-count":64,"journal-issue":{"issue":"11","published-print":{"date-parts":[[1991,11]]}},"alternative-id":["10.1002\/bies.950131109"],"URL":"https:\/\/doi.org\/10.1002\/bies.950131109","archive":["Portico"],"relation":{},"ISSN":["0265-9247","1521-1878"],"issn-type":[{"value":"0265-9247","type":"print"},{"value":"1521-1878","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,11]]},"assertion":[{"value":"2005-02-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}