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To prevent the deleterious consequences of DNA injury, an intricate network of repair systems has evolved. The biological impact of these repair mechanisms is illustrated by a number of genetic diseases that are characterized by a defect in one of the repair machineries and in general predispose individuals to cancer. This article intends to review our current understanding of the complex nucleotide excision repair pathway, a universal repair system with a broad lesion specificity. Emphasis will be on the recent advances in the genetic analysis of this process in mammalian cells.<\/jats:p>","DOI":"10.1002\/bies.950150405","type":"journal-article","created":{"date-parts":[[2005,2,25]],"date-time":"2005-02-25T09:25:27Z","timestamp":1109323527000},"page":"249-258","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Genes controlling nucleotide excision repair in eukaryotic cells"],"prefix":"10.1002","volume":"15","author":[{"given":"Geert","family":"Weeda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan H. 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