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The level of expression of each UDPGT isoform in the body is the result of interplay between temporal, tissue\u2010specific and environmental regulators. This complexity contributes to the difficulty in predicting the metabolic fate of compounds.<\/jats:p><jats:p>Genetic defects and polymorphisms affecting individual isoform activities have deleterious and potentially lethal effects, as exemplified by the severe hyperbilirubinaemia observed in Crigler\u2010Najjar Syndrome. Such severe genetic defects in bilirubin glucuronidation are obvious candidates for antenatal screening and gene therapy.<\/jats:p>","DOI":"10.1002\/bies.950151108","type":"journal-article","created":{"date-parts":[[2005,2,25]],"date-time":"2005-02-25T09:15:55Z","timestamp":1109322955000},"page":"749-754","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Human UDP\u2010glucuronosyl transferases: Chemical defence, jaundice and gene therapy"],"prefix":"10.1002","volume":"15","author":[{"given":"Catherine H.","family":"Brierley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Burchell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,2,5]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0168-9525(90)90174-5"},{"key":"e_1_2_1_3_2","volume-title":"Glucuronidation of Drugs and Other Compounds","author":"Dutton G. 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