{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T02:39:13Z","timestamp":1774665553878,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2005,2,5]],"date-time":"2005-02-05T00:00:00Z","timestamp":1107561600000},"content-version":"vor","delay-in-days":3445,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioEssays"],"published-print":{"date-parts":[[1995,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The development of the vertebrate skeleton is under complex genetic control, and good progress is being made towards identifying the genes responsible. A recent paper<jats:sup>(1)<\/jats:sup> contributes to this progress by describing transgenic mice in which the homeobox\u2010containing <jats:italic>MHox<\/jats:italic> gene has been disrupted. <jats:italic>MHox<\/jats:italic>(\u2212\/\u2212) mice have a range of skeletal defects, involving loss or shortening of structures in the skull, face and limb. Puzzling features of the <jats:italic>MHox<\/jats:italic>(\u2212\/\u2212) mutation, which has similar effects on bones with very different embryological origins and yet spares other bones completely, may hold clues to the mechanisms that shape the skeleton. <jats:italic>MHox<\/jats:italic>(\u2212\/\u2212) mice, used in conjunction with other skeletal mutants, will be important tools for exploring these mechanisms further.<\/jats:p>","DOI":"10.1002\/bies.950170903","type":"journal-article","created":{"date-parts":[[2005,2,25]],"date-time":"2005-02-25T09:12:51Z","timestamp":1109322771000},"page":"750-753","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["<i>Mhox<\/i> and vertebrate skeletogenesis: The long and the short of it"],"prefix":"10.1002","volume":"17","author":[{"given":"Paul M.","family":"Brickell","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,2,5]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.9.10.1237"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90487-5"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90626-2"},{"key":"e_1_2_1_5_2","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1242\/dev.120.1.209","article-title":"Bone morphogenetic proteins and a signalling pathway that controls pattern ng in the developing chick limb","volume":"120","author":"Francis P. 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