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They are characterized by many aberrations, ranging from the unusual compartmentation of metabolic pathways to the heresy of RNA editing. The ubiquitous phenomenon of glycosylphosphatidylinositol\u2010anchoring of eukaryotic plasma membrane proteins and RNA <jats:italic>trans<\/jats:italic>\u2010splicing (trypanosome genes contain no introns), which adds an identical leader sequence to all trypanosome mRNAs, were first defined during studies of antigenic variation. Genetic transformation of trypanosomes and the high efficiency of gene targeting provide new opportunities to investigate the regulation of antigenic variation. There is every reason to expect trypanosomes to provide further surprises and insights into the evolution of genetic regulatory mechanisms.<\/jats:p>","DOI":"10.1002\/bies.950180406","type":"journal-article","created":{"date-parts":[[2005,2,25]],"date-time":"2005-02-25T08:08:05Z","timestamp":1109318885000},"page":"283-291","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":195,"title":["Antigenic variation in trypansosomes: Secrets surface slowly"],"prefix":"10.1002","volume":"18","author":[{"given":"George A. 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