{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:30:58Z","timestamp":1786977058941,"version":"build-2736575974"},"reference-count":68,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2005,2,5]],"date-time":"2005-02-05T00:00:00Z","timestamp":1107561600000},"content-version":"vor","delay-in-days":3171,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioEssays"],"published-print":{"date-parts":[[1996,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Vulval development in the Caenorhabditis elegans hermaphrodite represents a simple, genetically tractable system for studying how cell signaling events control cell fata decisions. Current models suggest that proper specification of vulval cell fates relies on the integration of multiple signaling systems, including one that involves a receptor tyrosine kinase (RTK)\u2192Ras\u2192mitogen activated protein kinase (MAPK) cascade and one that involves a LIN\u201012\/Notch family receptor. In this review, we first discuss how genetic strategies are being used to identify and analyze components that control vulval cell fate decisions. We then describe the different signaling systems that have been elucidated and how they relate to one another. Finally, we highlight several recently characterized genes that encode positive regulators, negative regulators or potential targets of the RTK\u2192Ras\u2192MAPK cascade involved in vulval induction.<\/jats:p>","DOI":"10.1002\/bies.950180609","type":"journal-article","created":{"date-parts":[[2005,2,25]],"date-time":"2005-02-25T03:21:34Z","timestamp":1109301694000},"page":"473-480","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["Control and integration of cell signaling pathways during\n                    <i>C. Elegans<\/i>\n                    vulval development"],"prefix":"10.1002","volume":"18","author":[{"given":"Meera","family":"Sundaram","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,2,5]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(77)90158-0"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90293-Y"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90292-X"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/326259a0"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(80)90353-X"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(86)90842-1"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ge.27.120193.002433"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(81)90152-4"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/96.2.435"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/110.1.17"},{"key":"e_1_2_1_12_2","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1093\/genetics\/123.1.109","article-title":"The multivulva phenotype of certain C. elegans mutants results from defects in two functionally\u2010redundant pathways","volume":"123","author":"Ferguson E.","year":"1989","journal-title":"Genetics"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/348503a0"},{"key":"e_1_2_1_14_2","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1093\/genetics\/126.4.899","article-title":"The let\u201060 locus controls the switch between vulval and non\u2010vulval cell types in C. elegans","volume":"126","author":"Han M.","year":"1990","journal-title":"Genetics"},{"key":"e_1_2_1_15_2","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1093\/genetics\/128.2.251","article-title":"Multiple functions of let\u201023, a Caenorhabditis elegans receptor tyrosine kinase gene required for vulval induction","volume":"128","author":"Aroian R. 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