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The biochemistry and cellular biology of Xeroderma pigmentosum have been convincingly elucidated, but the same has not been true for Fanconi anaemia. In this review we consider the pleiotropic nature of Fanconi anaemia, its clinical and cellular variability and its genetic heterogeneity. We take into account the wealth of experimental findings available and offer a novel hypothesis involving feedback control of DNA replication during S phase of the cell cycle to explain the basic defect in the disease.<\/jats:p>","DOI":"10.1002\/bies.950180709","type":"journal-article","created":{"date-parts":[[2005,2,25]],"date-time":"2005-02-25T08:29:08Z","timestamp":1109320148000},"page":"579-585","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Molecular analysis of Fanconi anaemia"],"prefix":"10.1002","volume":"18","author":[{"given":"Martin","family":"Digweed","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl","family":"Sperling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,2,5]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00389636"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/356763a0"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/stem.5530120202"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V84.12.3995.bloodjournal84123995"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0959-8049(94)00485-N"},{"key":"e_1_2_1_7_2","first-page":"1829","article-title":"A high susceptiblity of Fanconi's anemia to chromosome breakage by DNA cross linking agents","volume":"33","author":"Sasaki M. 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