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Each polypeptide contains a short N\u2010terminal segment followed by a collagen\u2010like sequence and then by a C\u2010terminal lectin domain. A collectin molecule is assembled from identical or very similar polypeptides by disulphide bonds at the N\u2010terminal segment, formation of triple helices in the collagen\u2010like region and clusters of three lectin domains at the peripheral ends of triple helices. These proteins can bind to sugar residues on microorganisms <jats:italic>via<\/jats:italic> the peripheral lectin domains and subsequently interact, <jats:italic>via<\/jats:italic> the collagen\u2010like triple\u2010helices, with receptor(s) on phagocytes and\/or the complement system to bring about the killing and clearance of the targets without the involvement of antibodies. The collectins can also bind to phagocyte receptor(s) to enhance phagocytosis mediated by other phagocytic receptors. Lack, or low levels, of collectin expression can lead to higher susceptibility to infections, especially during childhood when specific immunity has not fully developed. Therefore, the collectins play important roles in the enhancement of innate immunity.<\/jats:p>","DOI":"10.1002\/bies.950190610","type":"journal-article","created":{"date-parts":[[2005,2,25]],"date-time":"2005-02-25T10:44:16Z","timestamp":1109328256000},"page":"509-518","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":73,"title":["Collectins: Collectors of microorganisms for the innate immune system"],"prefix":"10.1002","volume":"19","author":[{"given":"Jinhua","family":"Lu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,2,5]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.cb.09.110193.001321"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(94)90136-8"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/pro.5560030801"},{"key":"e_1_2_1_5_2","first-page":"6","article-title":"Similarity in structure between C1q and the collectins as judged by electron microscopy","volume":"93","author":"Lu J.","year":"1993","journal-title":"Behring Inst. 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