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In the mouse, the <jats:italic>caudal<\/jats:italic> homologue <jats:italic>Cdx2<\/jats:italic> has been implicated in directing early processes in intestinal morphogenesis and in the maintenance of the differentiated phenotype. A recent study showed that <jats:italic>Cdx2<\/jats:italic> null mutation was embryonically lethal, whereas <jats:italic>Cdx2<\/jats:italic><jats:sup>+\/\u2212<\/jats:sup> mice developed multiple intestinal polyps in the proximal colon in addition to developmental defects<jats:sup>(1)<\/jats:sup>. There are striking phenotypic similarities and differences between <jats:italic>Cdx2<\/jats:italic><jats:sup>+\/\u2212<\/jats:sup> and other mice predisposed to intestinal neoplasia. The possible role of <jats:italic>Cdx2<\/jats:italic> in human colorectal tumorigenesis is discussed.<\/jats:p>","DOI":"10.1002\/bies.950190705","type":"journal-article","created":{"date-parts":[[2005,2,25]],"date-time":"2005-02-25T10:44:27Z","timestamp":1109328267000},"page":"551-555","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Homeosis and polyposis: A tale from the mouse"],"prefix":"10.1002","volume":"19","author":[{"given":"Tong\u2010Chuan","family":"He","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis T.","family":"Da Costa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sam","family":"Thiagalingam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,2,5]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/386084a0"},{"key":"e_1_2_1_3_2","volume-title":"Materials for the Study of Variations","author":"Bateson W.","year":"1894"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90290-9"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-419X(89)90033-4"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/308428a0"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.81.13.4115"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(88)90209-7"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90292-5"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1985.tb04030.x"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(86)90516-7"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(85)90306-X"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/324537a0"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.2.12a.1647"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90104-3"},{"key":"e_1_2_1_16_2","doi-asserted-by":"crossref","first-page":"15229","DOI":"10.1016\/S0021-9258(17)36596-1","article-title":"Structure of the murine homeobox gene Cdx2: Expression in embryonic and adult intestinal epithelium","volume":"269","author":"James R.","year":"1994","journal-title":"J. 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