{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T11:58:01Z","timestamp":1790251081242,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2010,10,25]],"date-time":"2010-10-25T00:00:00Z","timestamp":1287964800000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biometrical J"],"published-print":{"date-parts":[[2010,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Dementia, Alzheimer's disease in particular, is one of the major causes of disability and decreased quality of life among the elderly and a leading obstacle to successful aging. Given the profound impact on public health, much research has focused on the age\u2010specific risk of developing dementia and the impact on survival. Early work has discussed various methods of estimating age\u2010specific incidence of dementia, among which the illness\u2010death model is popular for modeling disease progression. In this article we use multiple imputation to fit multi\u2010state models for survival data with interval censoring and left truncation. This approach allows semi\u2010Markov models in which survival after dementia depends on onset age. Such models can be used to estimate the cumulative risk of developing dementia in the presence of the competing risk of dementia\u2010free death. Simulations are carried out to examine the performance of the proposed method. Data from the Honolulu Asia Aging Study are analyzed to estimate the age\u2010specific and cumulative risks of dementia and to examine the effect of major risk factors on dementia onset and death.<\/jats:p>","DOI":"10.1002\/bimj.200900266","type":"journal-article","created":{"date-parts":[[2010,10,25]],"date-time":"2010-10-25T09:33:08Z","timestamp":1287999188000},"page":"616-627","source":"Crossref","is-referenced-by-count":14,"title":["Multiple imputation for estimating the risk of developing dementia and its impact on survival"],"prefix":"10.1002","volume":"52","author":[{"given":"Binbing","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane S.","family":"Saczynski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lenore","family":"Launer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,10,25]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1191\/0962280202SM276ra"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000093378"},{"key":"e_1_2_8_4_1","first-page":"1","article-title":"Dementia and its implications for public health","volume":"3","author":"Chapman D. 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