{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:35:40Z","timestamp":1786977340652,"version":"build-2736575974"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,5,11]],"date-time":"2018-05-11T00:00:00Z","timestamp":1525996800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Biometrical J"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Diagnostic or screening tests are widely used in medical fields to classify patients according to their disease status. Several statistical models for meta\u2010analysis of diagnostic test accuracy studies have been developed to synthesize test sensitivity and specificity of a diagnostic test of interest. Because of the correlation between test sensitivity and specificity, modeling the two measures using a bivariate model is recommended. In this paper, we extend the current standard bivariate linear mixed model (LMM) by proposing two variance\u2010stabilizing transformations: the arcsine square root and the Freeman\u2013Tukey double arcsine transformation. We compared the performance of the proposed methods with the standard method through simulations using several performance measures. The simulation results showed that our proposed methods performed better than the standard LMM in terms of bias, root mean square error, and coverage probability in most of the scenarios, even when data were generated assuming the standard LMM. We also illustrated the methods using two real data sets.<\/jats:p>","DOI":"10.1002\/bimj.201700101","type":"journal-article","created":{"date-parts":[[2018,5,11]],"date-time":"2018-05-11T04:03:36Z","timestamp":1526011416000},"page":"827-844","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Bivariate random\u2010effects meta\u2010analysis models for diagnostic test accuracy studies using arcsine\u2010based transformations"],"prefix":"10.1002","volume":"60","author":[{"given":"Zelalem F.","family":"Negeri","sequence":"first","affiliation":[{"name":"Department of Mathematics and Statistics McMaster University Hamilton ON Canada L8S 4K1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mateen","family":"Shaikh","sequence":"additional","affiliation":[{"name":"Department of Health Research Methods, Evidence, and Impact McMaster University Hamilton ON Canada L8S 4K1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0770-4444","authenticated-orcid":false,"given":"Joseph","family":"Beyene","sequence":"additional","affiliation":[{"name":"Department of Mathematics and Statistics McMaster University Hamilton ON Canada L8S 4K1"},{"name":"Department of Health Research Methods, Evidence, and Impact McMaster University Hamilton ON Canada L8S 4K1"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,5,11]]},"reference":[{"issue":"3","key":"e_1_2_9_2_1","first-page":"217","article-title":"On the likelihood of a time series model","volume":"27","author":"Akaike H.","year":"1978","journal-title":"Journal of the Royal Statistical Society. 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