{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T20:39:10Z","timestamp":1769546350842,"version":"3.49.0"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,3,11]],"date-time":"2021-03-11T00:00:00Z","timestamp":1615420800000},"content-version":"am","delay-in-days":365,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#am"},{"start":{"date-parts":[[2020,3,11]],"date-time":"2020-03-11T00:00:00Z","timestamp":1583884800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000121","name":"Division of Mathematical Sciences","doi-asserted-by":"publisher","award":["DMS\u20101914639"],"award-info":[{"award-number":["DMS\u20101914639"]}],"id":[{"id":"10.13039\/100000121","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Biometrical J"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Juvenile idiopathic arthritis (JIA) is a chronic disease. During its \u201chigh disease activity (HDA)\u201d stage, JIA can cause severe pain, and thus could seriously affect patients' physical and psychological health. Early detection of the HDA stage of JIA can reduce the damage of the disease by treating it at an early stage and alleviating the painful experience of the patients. So far, no effective cure of JIA has been found, and one major goal of disease management is to improve patients' quality of life. To this end, patients' health\u2010related quality of life (HRQOL) scores are routinely collected over time from JIA patients. In this paper, we demonstrate that a new statistical methodology called dynamic screening system (DySS) is effective for early detection of the HDA stage of JIA. By this approach, a patient's HRQOL scores are monitored sequentially, and a signal is given by DySS once the longitudinal pattern of the scores is found to be significantly different from the pattern of patients with low disease activity. Dimension reduction of the observed HRQOL scores and the corresponding impact on the performance of DySS are also\u00a0discussed.<\/jats:p>","DOI":"10.1002\/bimj.201900127","type":"journal-article","created":{"date-parts":[[2020,3,11]],"date-time":"2020-03-11T15:55:44Z","timestamp":1583942144000},"page":"1343-1356","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Early detection of high disease activity in juvenile idiopathic arthritis by sequential monitoring of patients' health\u2010related quality of life scores"],"prefix":"10.1002","volume":"62","author":[{"given":"Lu","family":"You","sequence":"first","affiliation":[{"name":"Department of Biostatistics University of Florida Gainesville FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Qiu","sequence":"additional","affiliation":[{"name":"Buchholz High School Gainesville FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Environmental Health University of Cincinnati Cincinnati OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4439-9466","authenticated-orcid":false,"given":"Peihua","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Biostatistics University of Florida Gainesville FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,3,11]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12969-016-0085-5"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24516"},{"key":"e_1_2_9_4_1","unstructured":"Consolaro A. Van Dijkhuizen P. Espada G. Varbanova B. Oliveira\u2010Knupp S. Miettunen P. \u2026Ravelli A.(2017 November).Development of new juvenile arthritis disease activity score cut\u2010offs for oligoarthritis and RF\u2010negative polyarthritis from a large multinational cohort of children with juvenile idiopathic arthritis. Paper presented at the 2017 ACR\/ARHP Annual Meeting San Diego CA."},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/00401706.1986.10488126"},{"key":"e_1_2_9_6_1","first-page":"1","article-title":"Directionally sensitive multivariate statistical process control methods with application to syndromic surveillance","volume":"3","author":"Fricker R. 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