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On the other hand, in longitudinal data, we often find features that do not impact modeling the response variable and are eliminated from the study. In this paper, we consider the problem of simultaneous variable selection and estimation in a multivariate t linear mixed\u2010effects model (MtLMM) for analyzing longitudinally measured multioutcome data. This work's motivation comes from a cohort study of patients with primary biliary cirrhosis. The interest is eliminating insignificant variables using the smoothly clipped and absolute deviation penalty function in the MtLMM. The proposed penalized model offers robustness and flexibility to accommodate fat tails. An expectation conditional maximization algorithm is employed for the computation of maximum likelihood estimates of parameters. The calculation of standard errors is affected by an information\u2010based method. The methodology is illustrated by analyzing Mayo Clinic Primary Biliary Cirrhosis sequential (PBCseq) data and a simulation study. We found drugs and sex can be eliminated from the PBCseq analysis, and over time the disease\u00a0progresses.<\/jats:p>","DOI":"10.1002\/bimj.202000015","type":"journal-article","created":{"date-parts":[[2021,11,26]],"date-time":"2021-11-26T09:40:42Z","timestamp":1637919642000},"page":"539-556","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Estimation in multivariate linear mixed models for longitudinal data with multiple outputs: Application to PBCseq data analysis"],"prefix":"10.1002","volume":"64","author":[{"given":"Mozhgan","family":"Taavoni","sequence":"first","affiliation":[{"name":"Department of Statistic Faculty of Mathematical Sciences Ferdowsi University of Mashhad Mashhad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5881-9241","authenticated-orcid":false,"given":"Mohammad","family":"Arashi","sequence":"additional","affiliation":[{"name":"Department of Statistic Faculty of Mathematical Sciences Ferdowsi University of Mashhad Mashhad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,11,25]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1541-0420.2010.01391.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.2517-6161.1977.tb01600.x","article-title":"Maximum likelihood estimation from incomplete data via the EM algorithm (with discussion)","volume":"39","author":"Dempster A. 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