{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T10:20:09Z","timestamp":1763202009348,"version":"3.45.0"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T00:00:00Z","timestamp":1747872000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Biometrical J"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Prostatectomized patients are at risk of resurgence, and for this reason, during a follow\u2010up period, they are monitored for prostate\u2010specific antigen (PSA) growth, an indicator of tumor progression. The presence of tumors can be evaluated with an expensive exam, called positron emission tomography with prostate\u2010specific membrane antigen (PET\u2010PSMA). To justify the high cost of the PET\u2010PSMA and, at the same time, to contain the risk for the patient, this exam should be recommended only when the evidence of tumor progression is strong. With the aim of estimating the optimal time to recommend the exam based on the patient's history and collected data, we build a hierarchical Bayesian model that describes, jointly, the PSA growth curve and the probability of a positive PET\u2010PSMA. With our proposal, we process all past and present information about the patients PSA measurement and PET\u2010PSMA results, in order to give an informed estimate of the optimal time, improving current\u00a0practice.<\/jats:p>","DOI":"10.1002\/bimj.70058","type":"journal-article","created":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T07:31:30Z","timestamp":1747899090000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Estimating the Optimal Time to Perform a Positron Emission Tomography With Prostate\u2010Specific Membrane Antigen in Prostatectomized Patients, Based on Data From Clinical Practice"],"prefix":"10.1002","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3514-6803","authenticated-orcid":false,"given":"Martina","family":"Amongero","sequence":"first","affiliation":[{"name":"Department of Economics Social Studies, Applied Mathematics, and Statistics Universit\u00e1 di Torino Torino Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianluca","family":"Mastrantonio","sequence":"additional","affiliation":[{"name":"Department of Mathematical Sciences Politecnico di Torino Torino Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"De Luca","sequence":"additional","affiliation":[{"name":"Department of Urology Universit\u00e1 di Torino Orbassano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8011-4005","authenticated-orcid":false,"given":"Mauro","family":"Gasparini","sequence":"additional","affiliation":[{"name":"Department of Mathematical Sciences Politecnico di Torino Torino Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,5,22]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-017-3711-7"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11222-008-9110-y"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2007.10.021"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/1467-9884.00117"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1992.03480160073037"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envsoft.2012.03.012"},{"volume-title":"The Frailty Model","year":"2008","author":"Duchateau L.","key":"e_1_2_11_8_1"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-410X.2002.02669.x"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2016.07.045"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2019.0096"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(19)30501-7"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1201\/9781482296426"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11222-013-9416-2"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1201\/b14835"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/jmcb\/mjs020"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.27239"},{"key":"e_1_2_11_18_1","unstructured":"International Agency for Research on Cancer.2022. \u201cCancer Today.\u201dhttps:\/\/gco.iarc.fr\/today\/en\/dataviz\/pie?mode=cancer."},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(96)00167-7"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/JU.0000000000001012"},{"key":"e_1_2_11_21_1","unstructured":"Memorian Sloan Kattering Cancer Center.1999\u201cPSA Doubling Time.\u201dhttps:\/\/www.mskcc.org\/nomograms\/prostate\/psa_doubling_time."},{"key":"e_1_2_11_22_1","first-page":"580","volume-title":"Proceedings of the Social Statistics Section","author":"Pearson J. 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