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In this study high\u2010quality CdSe QDs prepared in a paraffin\u2013oleic acid system were used as fluorescent labels in direct and indirect detection of carcinoembryonic antigen (CEA), a cancer marker expressed on the surface of HeLa cells. The primary antibody (Ab) (rabbit anti\u2010CEA8) and secondary Ab (goat anti\u2010rabbit IgG) were covalently linked to carboxyl\u2010functioned CdSe QDs, and both the QDs\u2013antibody and QDs\u2013IgG probes were successfully used to label HeLa cells. The present study demonstrates the practicability of CdSe QDs as an attractive type of fluorescent labels for biological applications such as protein probes and cell imaging. 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