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This cell stably expresses firefly luciferase and produces light that can be detected using an <jats:italic>in vivo<\/jats:italic> imaging system (IVIS). Parental HM\u20101 cells cause severe carcinomatous peritonitis to B6C3F1 mice, but not to C57BL6 mice. Established HM\u20101\/luc cells showed pathologically similar findings to HM\u20101 cells. HM\u20101\/luc cells were injected into the peritoneal cavity of B6C3F1 mice and IVIS 2000 was conducted weekly after inoculation to monitor intra\u2010peritoneal tumor growth. The mice were divided into three groups: non\u2010CDDP\u2010treated (control) and CDDP\u2010treated (0.2 and 0.4\u2009mg). A disease\u2010suppressive effect of the CDDP was reflected by the significantly prolonged survival of the CDDP\u2010treated mice (control 23\u2009\u00b1\u20091.9 days, CDDP 0.2\u2009mg 29.6\u2009\u00b1\u20092.9 days; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05); the total photon and area of flux were decreased. The optical imaging of intraperitoneal tumors via <jats:italic>in vivo<\/jats:italic> bioluminescence is effective for noninvasive monitoring and semi\u2010quantitative analysis. Our syngeneic mouse model has the relevant clinical features of ovarian cancer, which makes it a useful model for developing new ovarian cancer therapies. Copyright \u00a9 2009 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/bio.1112","type":"journal-article","created":{"date-parts":[[2009,8,27]],"date-time":"2009-08-27T03:03:08Z","timestamp":1251342188000},"page":"324-331","source":"Crossref","is-referenced-by-count":17,"title":["Generation of a syngeneic mouse model to study the intraperitoneal dissemination of ovarian cancer with <i>in vivo<\/i> luciferase imaging"],"prefix":"10.1002","volume":"24","author":[{"given":"Masafumi","family":"Toyoshima","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinori","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuyo","family":"Matumoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miyuki","family":"Yamazaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoru","family":"Nagase","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuo","family":"Sugamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuo","family":"Yaegashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,8,27]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.3322\/canjclin.56.2.106"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1123"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2004.08.013"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2007.10.035"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.01.007"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/21.4.585"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1593\/neo.05358"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64505-1"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-04-1924"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.MCR-07-0001"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.1989.tb02336.x"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1006537013317"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-001-0396-0"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00833392"},{"key":"e_1_2_1_16_2","first-page":"1155","article-title":"Biological and pharmacological characterisation of three models of human ovarian carcinoma established in nude mice: use of the CA125 tumour marker to predict antitumour activity","volume":"15","author":"Burbridge MF","year":"1999","journal-title":"Int. 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