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The sharp and narrow emission peaks showed that the as\u2010prepared QDs have desirable dispersibility, uniformity and good fluorescence properties. Both CdTe\u2013BSA and CdTe\u2013CD4 conjugates showed an enhancement of fluorescence intensity over that of bare CdTe QDs. The experimental result of gel electrophoresis confirmed the successful conjugation of CdTe\u2013BSA and CdTe\u2013CD4. The fluorescent microscopic images of CdTe\u2013CD4 labeled mouse T\u2010lymphocyte cells and mouse spleen tissue were compared with that obtained from fluorescein isothiocyanate labeling. It was demonstrated that the CdTe QDs\u2010based probe exhibited much better photostability and fluorescence intensity than fluorescein isothiocyanate, showing a good application potential in the immuno\u2010labeling of cells and tissues. 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