{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T05:10:24Z","timestamp":1698037824298},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,3,30]],"date-time":"2005-03-30T00:00:00Z","timestamp":1112140800000},"content-version":"vor","delay-in-days":5567,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Biolumin. Chemilumin."],"published-print":{"date-parts":[[1990,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A severe dysfunction in the cellular response of human polymorphonuclear leukocytes (PMNL) to non\u2010opsonized zymosan was observed under a deficiency of extracellular Mg<jats:sup>2+<\/jats:sup>. The phagocytosis\u2010association native (luminol\u2010independent) luminescence (NL), as well as luminol\u2010dependent luminescence (LDL) (detected simultaneously and discriminated by spectral methods), was strongely inhibited. Apart from a general decrease of total light production, a Mg<jats:sup>2+<\/jats:sup>\u2010concentration\u2010dependent delay of the maximum of NL and LDL was observed. A disorder in recruitment of activated membrane\u2010bound NADPH\u2010oxidase of PMNL is suggested. The presence of extracellular Ca<jats:sup>2+<\/jats:sup> did not compensate for the Mg<jats:sup>2+<\/jats:sup> deficit. In the presence of Mg<jats:sup>2+<\/jats:sup> only a slight Ca<jats:sup>2+<\/jats:sup>\u2010dependent reduction of NL was obtained, but Ca<jats:sup>2+<\/jats:sup> seemed to selectively promote LDL. This may indicate a positive influence of Ca<jats:sup>2+<\/jats:sup> on the myeloperoxidase release from the cells. Experiments with the metalions\u2010chelating agents EDTA and EGTA, which complex Mg<jats:sup>2+<\/jats:sup> to differing extents, confirmed the important role of Mg<jats:sup>2+<\/jats:sup> in PMNL\u2010activation by non\u2010opsonized zymosan.<\/jats:p>","DOI":"10.1002\/bio.1170050107","type":"journal-article","created":{"date-parts":[[2005,5,29]],"date-time":"2005-05-29T00:04:49Z","timestamp":1117325089000},"page":"31-36","source":"Crossref","is-referenced-by-count":2,"title":["Magnesium\u2010dependent induction of phagocytosis\u2010associated chemiluminescence of adherent human polymorphonuclear leukocytes by non\u2010opsonized zymosan"],"prefix":"10.1002","volume":"5","author":[{"given":"Paul","family":"Roschger","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Graninger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Herbert","family":"Klima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,3,30]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/312315a0"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","unstructured":"Boxer G. 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