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The aim of the study was to examine whether a respiratory burst stimulation by neutrophils would be observed by neutrophil\/endothelial cell interaction and whether the respiratory burst stimulation of neutrophils by endothelial cells could be enhanced by lipopolysaccharide stimulation of neutrophils. The second aim was whether such an effect, or secretion of elastase, could cause an endothelial cell damage <jats:italic>in vitro<\/jats:italic>.<\/jats:p><jats:p>Chemiluminescence as an indicator of oxygen\u2010derived metabolites produced by neutrophils, elastase release by neutrophils, and endothelial cell damage, based on<jats:sup>111<\/jats:sup> In\u2010oxine release from labelled endothelial cells, were measured simultaneously. The present investigation demonstrates that neutrophils can be directly stimulated by endothelial cells. A further amplification of this process following lipopolysaccharide priming up to 10 ng\/ml blood could be demonstrated. A slight endothelial cell damage occurs following neutrophil stimulation, although elastase secretion does not increase during interaction between neutrophils and endothelial cells. These results raise the possibility that oxygen\u2010derived metabolites rather than elastase contribute to an endothelial cell damage which might occur in conditions such as endotoxin\u2010induced adult respiratory distress syndrome.<\/jats:p>","DOI":"10.1002\/bio.1170060106","type":"journal-article","created":{"date-parts":[[2005,5,29]],"date-time":"2005-05-29T00:06:21Z","timestamp":1117325181000},"page":"19-27","source":"Crossref","is-referenced-by-count":7,"title":["Simultaneous measurement of endothelial cell damage, elastase release and chemiluminescence response during interaction between polymorphonuclear leukocytes and endothelial cells"],"prefix":"10.1002","volume":"6","author":[{"given":"Eleonore","family":"Jonas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Dwenger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Britta","family":"Lueken","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrich","family":"Boehme","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,3,30]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"578","article-title":"Loss of 51 chromium, lactate dehydrogenase, and 111Indium as indicators of endothelial injury","volume":"57","author":"Chopra J.","year":"1987","journal-title":"Lab. 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