{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T14:37:53Z","timestamp":1761662273043},"reference-count":16,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,3,30]],"date-time":"2005-03-30T00:00:00Z","timestamp":1112140800000},"content-version":"vor","delay-in-days":3621,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Biolumin. Chemilumin."],"published-print":{"date-parts":[[1995,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The effect of different concentrations (0.87, 4.35, 8.7, 17.5, 25 and 35 mg\/mL) of intravenous immunoglobulin G (Endobulin\u00ae) on neutrophil\u2013endothelial cell interaction was studied using an <jats:italic>in vitro<\/jats:italic> model of human umbilical cord vein endothelial cells and human neutrophils. Because adherence of neutrophils to endothelial cells is an essential component in inflammatory processes leading to endothelial cell injury the influence of immunoglobulin G on adherence has been investigated.<\/jats:p><jats:p>A second aim of the present study was to determine changes in chemiluminescence response of neutrophils during adherence to endothelial cells. Production of oxygen\u2010derived metabolites, measured by chemiluminescence response of neutrophils, decreased significantly in the presence of 8.7 mg immunoglobulin\/mL test during coincubation of neutrophils and endothelial cells (<jats:italic>p<\/jats:italic> &lt; 0.025). The adherence of neutrophils to endothelial cells was significantly decreased at a concentration of 8.7 mg immunoglobulin\/mL test (<jats:italic>p<\/jats:italic> &lt; 0.025).<\/jats:p><jats:p>The present results indicate that this preparation of immunoglobulin G might exert a protective effect on neutrophil\u2013endothelial cell interaction by decreasing adherence of neutrophils to endothelial cells and by scavenging reactive oxygen metabolites. Therefore, the current investigation points to a probable protective effect of immunoglobulin G in oxidative diseases, such as the adult respiratory distress syndrome.<\/jats:p>","DOI":"10.1002\/bio.1170100305","type":"journal-article","created":{"date-parts":[[2005,5,29]],"date-time":"2005-05-29T00:13:04Z","timestamp":1117325584000},"page":"169-173","source":"Crossref","is-referenced-by-count":7,"title":["Chemiluminescence response and adherence of neutrophils to cultured endothelial cells\u2013influence of immunoglobulin G"],"prefix":"10.1002","volume":"10","author":[{"given":"Eleonore","family":"Jonas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Dwenger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Jonas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,3,30]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"977","article-title":"Opsonic activity of immunoglobulin prepared for intravenous use","volume":"104","author":"Hetherington SV","year":"1984","journal-title":"J Lab Clin Med"},{"key":"e_1_2_1_3_2","first-page":"161","article-title":"Interaction of human IgG preparations with polymorphonuclear leukocytes in vitro","volume":"92","author":"Koch C","year":"1984","journal-title":"Acta Pathol Microbiol Immunol Scand 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