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The synthesis conditions were systematically optimized, which included the size of CdTe core, the refluxing time and the number of monolayers and the ligands, and then the chemical and optical properties of the as\u2010prepared products were investigated. We found that the mercaptopropionic acid (MPA)\u2010coated CdTe\/CdS\/ZnS QDs presented highly photoluminescent quantum yields (PL QYs), good photostability and chemical stability, good salt tolerance and pH tolerance and favorable biocompatibility. The characterization of high\u2010resolution transmission electron microscopy (HRTEM), X\u2010ray powder diffraction (XRD) and fluorescence correlation spectroscopy (FCS) showed that the CdTe\/CdS\/ZnS QDs had good monodispersity and crystal structure. The fluorescence life time spectra demonstrated that CdTe\/CdS\/ZnS QDs had a longer lifetime in contrast to fluorescent dyes and CdTe QDs. Furthermore, the MPA\u2010stabilized CdTe\/CdS\/ZnS QDs were applied for the imaging of cells. Compared with current synthesis methods, our synthesis approach was reproducible and simple, and the reaction conditions were mild. More importantly, our method was cost\u2010effective, and was very suitable for large\u2010scale synthesis of CdTe\/CdS\/ZnS QDs for future applications. Copyright \u00a9 2010 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/bio.1250","type":"journal-article","created":{"date-parts":[[2010,9,27]],"date-time":"2010-09-27T04:48:21Z","timestamp":1285562901000},"page":"439-448","source":"Crossref","is-referenced-by-count":42,"title":["Aqueous synthesis of CdTe\/CdS\/ZnS quantum dots and their optical and chemical 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