{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T00:01:53Z","timestamp":1783728113563,"version":"3.55.0"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2011,3,17]],"date-time":"2011-03-17T00:00:00Z","timestamp":1300320000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Luminescence"],"published-print":{"date-parts":[[2011,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>The tetracycline family antibiotics are widely used as human and veterinary treatments. The drugs are effective as antibiotics and also show antimicrobial and non\u2010microbial action. However, the antioxidant properties of tetracyclines have not been characterized in aprotic media. To better understand their biological functions, the <jats:italic>in vitro<\/jats:italic> superoxide anion radical (<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/bio1283-math-0001.gif\" xlink:title=\"urn:x-wiley:15227235:media:bio1283:bio1283-math-0001\"\/>) scavenging activities of tetracycline, chlortetracycline, oxytetracycline, doxycycline and methacycline were characterized, along with a very efficient <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/bio1283-math-0002.gif\" xlink:title=\"urn:x-wiley:15227235:media:bio1283:bio1283-math-0002\"\/> scavenger, tiron, in dimethyl sulphoxide (DMSO), using ultra\u2010weak chemiluminescence (CL). We found that tetracycline, chlortetracycline and doxycycline efficiently inhibited CL from the <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/bio1283-math-0003.gif\" xlink:title=\"urn:x-wiley:15227235:media:bio1283:bio1283-math-0003\"\/>\u2010generating system at concentration levels of 0.02\u20131.0\u2009mmol\/L. Methacycline and oxytetracycline were the <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/bio1283-math-0004.gif\" xlink:title=\"urn:x-wiley:15227235:media:bio1283:bio1283-math-0004\"\/>scavengers at concentration levels of 0.01\u20130.1\u2009mmol\/L, whereas when their concentration was lowered the drugs were capable of generating <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/bio1283-math-0005.gif\" xlink:title=\"urn:x-wiley:15227235:media:bio1283:bio1283-math-0005\"\/>, leading to CL enhancement. For all the data obtained in this study, the scavenging activity for the compounds tested decreased in the following order: tetracycline\u2009&gt;\u2009doxycycline\u2009&gt;\u2009chlortetracycline\u2009&gt;\u2009tiron methacycline\u2009&gt;\u2009oxytetracycline. These results indicate that the tetracycline drugs directly alter <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/bio1283-math-0006.gif\" xlink:title=\"urn:x-wiley:15227235:media:bio1283:bio1283-math-0006\"\/> redox chemistry in aprotic media. Copyright \u00a9 2011 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/bio.1283","type":"journal-article","created":{"date-parts":[[2011,3,17]],"date-time":"2011-03-17T04:04:21Z","timestamp":1300334661000},"page":"611-615","source":"Crossref","is-referenced-by-count":18,"title":["Characterization of the superoxide anion radical scavenging activity by tetracycline antibiotics in aprotic media"],"prefix":"10.1002","volume":"26","author":[{"given":"Aleksandra","family":"K\u0142adna","sequence":"first","affiliation":[{"name":"Department of Medical History and Ethics Pomeranian Medical University of Szczecin  ul. Rybacka 1 70\u2013204 Szczecin Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irena","family":"Kruk","sequence":"additional","affiliation":[{"name":"Institute of Physics, Faculty of Mechanical Engineering and Mechatronics West Pomeranian University of Technology in Szczecin  Al. Piast\u00f3w 48\/49 70\u2013311 Szczecin Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Michalska","sequence":"additional","affiliation":[{"name":"Institute of Physics, Faculty of Mechanical Engineering and Mechatronics West Pomeranian University of Technology in Szczecin  Al. Piast\u00f3w 48\/49 70\u2013311 Szczecin Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pawe\u0142","family":"Berczy\u0144ski","sequence":"additional","affiliation":[{"name":"Institute of Physics, Faculty of Mechanical Engineering and Mechatronics West Pomeranian University of Technology in Szczecin  Al. Piast\u00f3w 48\/49 70\u2013311 Szczecin Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hassan Y.","family":"Aboul\u2010Enein","sequence":"additional","affiliation":[{"name":"Pharmaceutical and Medicinal Chemistry Department Pharmaceutical and Drug Industries Research Division, National Research Centre  Dokki Cairo 12311 Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,3,17]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/10807030701506223"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0045-6535(97)00354-8"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0043-1354(03)00399-3"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02736854"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2008.12.012"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkg293"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2005.06.030"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2005.04.006"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1039\/p29790000369"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/1011-1344(92)85112-8"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/1011-1344(92)80018-Q"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12263531"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2010.05.063"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotochem.2006.09.009"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2007.05.059"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2009.11.024"},{"key":"e_1_2_4_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.watres.2010.06.020"},{"key":"e_1_2_4_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2010.10.007"},{"key":"e_1_2_4_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2004.03.033"},{"key":"e_1_2_4_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2006.02322.x"},{"key":"e_1_2_4_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0891-5849(88)90106-2"},{"key":"e_1_2_4_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/1011-1344(93)80093-O"},{"key":"e_1_2_4_24_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.8.6.713"},{"key":"e_1_2_4_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(84)05010-2"},{"key":"e_1_2_4_26_1","first-page":"219","volume-title":"Bioluminescence and Chemiluminescence: Fundamentals and Applied Aspects","author":"Suzuki N","year":"1994"},{"key":"e_1_2_4_27_1","first-page":"25","article-title":"Use of a free radical method to evaluate antioxidant activity","volume":"28","author":"Brand\u2010Williams W","year":"1995","journal-title":"Technology"},{"key":"e_1_2_4_28_1","volume-title":"Druga twarz tlenu. 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