{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T22:57:26Z","timestamp":1790377046650,"version":"4.1.0"},"reference-count":44,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2011,8,23]],"date-time":"2011-08-23T00:00:00Z","timestamp":1314057600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Luminescence"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Tetracyclines are the second most common antibiotic family in medicine usage. These antibiotics exhibit antioxidant potential; however, the exact mechanism remains unclear. The antiradical activity of the seven tetracyclines (TCs; tetracycline, chlortetracycline, oxytetracycline, doxocycline, methacycline, demeclocycline, minocycline) was determined using the free radical 2,2\u2010diphenyl\u20101\u2010picrylhydrazyl (DPPH<jats:sup>\u2022<\/jats:sup>) and hydroxyl radicals (HO<jats:sup>\u2022<\/jats:sup>) generated in a Fenton reaction. Electron spin resonance (ESR), ESR spin\u2010trapping, chemiluminescence and spectrophotometry techniques were applied. It was found that the TCs showed high DPPH antiradical activity in the range 26\u201396% at 2.5\u2009mmol\/L concentration. The second\u2010order rate constants for the reaction between HO<jats:sup>\u2022<\/jats:sup> and TCs were calculated, in the range (3.6\u20139.6) \u00d7 10<jats:sup>9<\/jats:sup>\u2009L\/mol\/s. The tetracycline compounds also exhibited a strong decrease in light emission (range 61\u201385% at concentration of 1\u2009mmol\/L). This study also showed that TCs promote the generation of singlet oxygen in the presence of <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/bio1339-math-0001.gif\" xlink:title=\"urn:x-wiley:15227235:media:bio1339:bio1339-math-0001\"\/> and Fe(II)\/Fe(III) ions. Our findings suggest direct scavenging activity of the examined tetracyclines towards free radicals, and may be relevant to therapeutic strategy. Copyright \u00a9 2011 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/bio.1339","type":"journal-article","created":{"date-parts":[[2011,8,31]],"date-time":"2011-08-31T17:23:36Z","timestamp":1314811416000},"page":"249-255","source":"Crossref","is-referenced-by-count":47,"title":["Evaluation of the antioxidant activity of tetracycline antibiotics <i>in vitro<\/i>"],"prefix":"10.1002","volume":"27","author":[{"given":"Aleksandra","family":"K\u0142adna","sequence":"first","affiliation":[{"name":"Department of Medical History and Ethics Pomeranian Medical Academy  ul. Rybacka 1 70\u2010204 Szczecin Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Michalska","sequence":"additional","affiliation":[{"name":"Institute of Physics Faculty of Mechanical Engineering and Mechatronics  al. 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