{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T01:02:30Z","timestamp":1759971750488,"version":"build-2065373602"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,1,18]],"date-time":"2012-01-18T00:00:00Z","timestamp":1326844800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Luminescence"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>A simple, rapid and sensitive chemiluminescent (CL) method for the assay of venlafaxine (VEN) in pharmaceutical formulations and serum samples by a two\u2010chip device is proposed. The method is based on the reaction of this drug with a tris(2,2\u2032\u2010bipyridyl) ruthenium(II)\u2013peroxydisulphate CL system. The optimum chemical conditions for CL emission were investigated. The calibration graph was linear for the concentration range 0.02\u20138.0\u2009\u00b5g\/mL. The detection and quantification limits were found to be 0.006 and 0.018\u2009\u00b5g\/mL, respectively, while the relative standard deviation (RSD) was &lt;2.0%. The present CL procedure was applied to the determination of VEN in pharmaceutical formulations and serum samples; the recovery levels were in the range 96.5\u2013101.2%. The results suggest that the method is unaffected by the presence of common formulation excipients found in these samples. Copyright \u00a9 2012 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/bio.2334","type":"journal-article","created":{"date-parts":[[2012,1,18]],"date-time":"2012-01-18T08:08:36Z","timestamp":1326874116000},"page":"44-49","source":"Crossref","is-referenced-by-count":9,"title":["High\u2010throughput method for the analysis of venlafaxine in pharmaceutical formulations and biological fluids, using a tris(2,2\u2032\u2010bipyridyl) ruthenium(II)\u2013peroxydisulphate chemiluminescence system in a two\u2010chip device"],"prefix":"10.1002","volume":"28","author":[{"given":"Haider A. J.","family":"Al Lawati","sequence":"first","affiliation":[{"name":"Department of Chemistry, College of Science Sultan Qaboos University  Al\u2010Khod Oman"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gouri B.","family":"Varma","sequence":"additional","affiliation":[{"name":"Department of Chemistry, College of Science Sultan Qaboos University  Al\u2010Khod Oman"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fakhr Eldin O.","family":"Suliman","sequence":"additional","affiliation":[{"name":"Department of Chemistry, College of Science Sultan Qaboos University  Al\u2010Khod Oman"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,1,18]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2006.11.021"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2010.03.043"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2006.12.019"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2005.03.006"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2008.05.024"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2008.02.015"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2010.01.007"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2005.09.034"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0731-7085(01)00701-4"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2006.12.035"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4347(01)00270-5"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2007.05.046"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2008.06.052"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4347(97)00426-X"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.2116\/analsci.21.1515"},{"key":"e_1_2_6_17_1","first-page":"866","article-title":"Rapid determination of venlafaxine hydrochloride by chemiluminescence method","volume":"17","author":"Zhang Q\u2010X","year":"2008","journal-title":"Chin J New Drugs"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2011.04.072"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1201\/9781482270693"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/bio.1310"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2010.08.018"}],"container-title":["Luminescence"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbio.2334","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bio.2334","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T16:26:02Z","timestamp":1759940762000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/bio.2334"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1,18]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["10.1002\/bio.2334"],"URL":"https:\/\/doi.org\/10.1002\/bio.2334","archive":["Portico"],"relation":{},"ISSN":["1522-7235","1522-7243"],"issn-type":[{"type":"print","value":"1522-7235"},{"type":"electronic","value":"1522-7243"}],"subject":[],"published":{"date-parts":[[2012,1,18]]}}}