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An interfaced CdS layer sandwiched between a CdTe core and ZnO shell provided relaxation of the strain at the core\/shell interface since lattice parameters of CdS are intermediate between those of CdTe and ZnO. The photoluminescence (PL) peak wavelength of the core\/shell\/shell QDs was shifted from 569 to 615\u2009nm by adjusting the size of CdTe cores and thickness of CdS and ZnO shells, along with the highest PL quantum yield of the core\/shell\/shell QDs reaching 80%, which implies promising applications in the field of biomedical labeling. Due to the decrease of surface defects, it was observed that PL lifetimes significantly increased at room temperature as follows: 29.6 34.2, and 47.5\u2009ns for CdTe (537\u2009nm), CdTe\/CdS (555\u2009nm) and CdTe\/CdS\/ZnO (581\u2009nm) QDs, respectively. 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