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The method was based on condensation of malonic acid\/acetic anhydride (MAA) under the catalytic effect of the tertiary amine moiety of the studied phenothiazines to provide a deep yellow to brown colour with green florescence. Relative fluorescence intensity of the products was measured at \u03bb<jats:sub>exc<\/jats:sub> 398\u2009nm and \u03bb<jats:sub>em<\/jats:sub> 432\u2009nm. Different variables affecting the reaction were studied and optimized. The method was successfully applied for the determination of the studied drugs in commercial dosage forms. The lower detection limits allowed the application of this method for the determination of the compounds in plasma as an example of a biological fluid. In addition, the method was considered specific for the determination of tertiary amines in the presence of primary and secondary amines; as a result, it was deemed suitable for the determination of the cited drugs in the presence of their degradation products resulting from N\u2010dealkylation or oxidation of the corresponding sulphoxides or sulphones. 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