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Under optimum conditions, luminescence of CdTe nanocrystals (\u03bb<jats:sub>ex<\/jats:sub>\u2009=\u2009365\u2009nm, \u03bb<jats:sub>em<\/jats:sub>\u2009=\u2009562\u2009nm) was quenched by OTC in a concentration\u2010dependent manner best described by a modified Stern\u2010Volmer type equation. Good linearity was obtained with a regression coefficient of 0.9999 in the range of 1.34\u2009~\u200913.4 x 10<jats:sup>\u20105<\/jats:sup>\u2009mol\/L and a limit of detection of 3.08 x 10<jats:sup>\u20107<\/jats:sup>\u2009mol\/L. In addition, the quenching mechanism was also established. The results imply that the close proximity of OTC\u2010CdTe was driven by electrostatic attraction and the resulting effective electron transfer from OTC to QDs could be responsible for fluorescence quenching of CdTe\u2010QDs. Copyright \u00a9 2012 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/bio.2393","type":"journal-article","created":{"date-parts":[[2012,6,19]],"date-time":"2012-06-19T12:34:04Z","timestamp":1340109244000},"page":"378-383","source":"Crossref","is-referenced-by-count":26,"title":["A novel fluorescent assay for oxytetracycline hydrochloride based on fluorescence quenching of water\u2010soluble CdTe nanocrystals"],"prefix":"10.1002","volume":"28","author":[{"given":"Chao","family":"Gao","sequence":"first","affiliation":[{"name":"Department of Analytical Chemistry China Pharmaceutical University  Nanjing 210009 China"},{"name":"Key Laboratory of Drug Quality Control and Pharmacovigilance, Ministry of Education China Pharmaceutical University  Nanjing 210009 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry China Pharmaceutical University  Nanjing 210009 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