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Lifestyle parameters (smoking, alcohol consumption, and exercise habits), HbA1c and neutrophil function such as reactive oxygen species (ROS) production capability and phagocytic activity (PA) were measured. ROS production capability was measured before and after phagocytic stimulus to obtain basal ROS production and stimulated ROS production. Level of HbA1c had a positive correlation with basal ROS production (p=0.053), a negative correlation with stimulated ROS production (p=0.072) and PA (p=0.059) only in post\u2010menopausal groups, and not in pre\u2010menopausal groups. However, there were no correlations between levels of HbA1c and neutrophil functions in male. In conclusion, in the present study, despite the presence of diabetes, chronic hyperglycemia was found to cause an increase in daily basal ROS production of neutrophils, and increased susceptibility to infection caused by reduced neutrophilic reaction in females in their menopause. Therefore, from the oxidative point of view, strict glycemic control is necessary to prevent post\u2010menopausal females from developing diabetic complications in spite of the presence of diabetes.<\/jats:p>","DOI":"10.1002\/bio.2495","type":"journal-article","created":{"date-parts":[[2013,3,26]],"date-time":"2013-03-26T06:13:17Z","timestamp":1364278397000},"page":"569-573","source":"Crossref","is-referenced-by-count":25,"title":["The influence of blood glucose on neutrophil function in individuals without diabetes"],"prefix":"10.1002","volume":"28","author":[{"given":"Yuriko","family":"Saito","sequence":"first","affiliation":[{"name":"Department of Social Medicine Hirosaki University Graduate School of Medicine  Hirosaki Aomori Japan"},{"name":"Department of Plastic and Reconstructive Surgery Hirosaki University Graduate School of Medicine  Hirosaki Aomori Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ippei","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Social Medicine Hirosaki University Graduate School of Medicine  Hirosaki Aomori Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaori","family":"Iwane","sequence":"additional","affiliation":[{"name":"Department of Social Medicine Hirosaki University Graduate School of Medicine  Hirosaki Aomori Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriyuki","family":"Okubo","sequence":"additional","affiliation":[{"name":"Department of Social Medicine Hirosaki University Graduate School of Medicine  Hirosaki Aomori Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miya","family":"Nishimura","sequence":"additional","affiliation":[{"name":"Hirosaki University Graduate School of Health Sciences  Hirosaki Aomori Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Matsuzaka","sequence":"additional","affiliation":[{"name":"Department of Social Medicine Hirosaki University Graduate School of Medicine  Hirosaki Aomori Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoko","family":"Wada","sequence":"additional","affiliation":[{"name":"Department of Social Medicine Hirosaki University Graduate School of Medicine  Hirosaki Aomori Japan"},{"name":"Department of Plastic and Reconstructive Surgery Hirosaki University Graduate School of Medicine  Hirosaki Aomori Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Miwa","sequence":"additional","affiliation":[{"name":"Department of Social Medicine Hirosaki University Graduate School of Medicine  Hirosaki Aomori Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Umeda","sequence":"additional","affiliation":[{"name":"Department of Social Medicine Hirosaki University Graduate School of Medicine  Hirosaki Aomori Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeyuki","family":"Nakaji","sequence":"additional","affiliation":[{"name":"Department of Social Medicine Hirosaki University Graduate School of Medicine  Hirosaki Aomori Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,3,19]]},"reference":[{"key":"e_1_2_5_2_1","unstructured":"International Diabetes Federation [Internet].Brussels Belgium: IDF Diabetes Atlas. 5th edition [updated 2011; cited 10 September 2012]. 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