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The results of high\u2010resolution transmission electron microscopy and transmission electron microscopy show that CdSe QDs and QDs\u2010encapsulated GNPs (QDs\u2010GNPs) have average diameters of 5\u2009\u00b1\u20091 and 150\u2009\u00b1\u200910 nm, respectively. Results of both high\u2010resolution transmission electron microscopy and confocal laser scanning microscopy indicate that CdSe QDs are successfully encapsulated within GNPs. The QDs\u2010GNPs have distinctive fluorescent properties with maximum emission at 654 nm, with a 24 nm red\u2010shift comapred with hydrophilic mercaptoundecanoic acid (MUA)\u2010modified QDs. In addition, an <jats:italic>in vitro<\/jats:italic> cytotoxicity test shows that QDs\u2010GNPs do not have any toxic effect on cells. It is expected that QDs\u2010GNPs might be an excellent candidate as a contrast agent in bio\u2010imaging. 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