{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T05:48:33Z","timestamp":1777441713311,"version":"3.51.4"},"reference-count":23,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2014,3,3]],"date-time":"2014-03-03T00:00:00Z","timestamp":1393804800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Luminescence"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>An automated multi\u2010pumping flow system is proposed for the chemiluminometric determination of ascorbic acid in pharmaceutical formulations, relying on the ability of semiconductor nanocrystals to generate short\u2010lived reactive species upon photo\u2010irradiation. A photo\u2010unit based on visible\u2010light\u2010emitting diodes is used to photo\u2010excite cadmium telluride (CdTe) quantum dots capped with glutathione, leading to the generation of radicals that react with luminol under alkaline conditions, yielding the chemiluminescence. Ascorbic acid acts as a radical scavenger, preventing the oxidation of luminol, thus ensuring a concentration\u2010dependent chemiluminescence quenching. After system optimization, a linear working range of 5.0\u2009\u00d7\u200910<jats:sup>\u20107<\/jats:sup> to 5.0\u2009\u00d7\u200910<jats:sup>\u20106<\/jats:sup>\u2009mol\/L ascorbic acid (<jats:italic>r<\/jats:italic>\u2009=\u20090.9967, <jats:italic>n<\/jats:italic>\u2009=\u20095) was attained, with a detection limit of 3.05\u2009\u00d7\u200910<jats:sup>\u20107<\/jats:sup>\u2009mol\/L and a sampling rate of 200\/h. The flow system was applied to the analysis of pharmaceutical formulations and the results were in good agreement with those obtained by the reference titrimetric procedure (RD\u2009&amp;#60;\u2009\u00b1 4.3%, <jats:italic>n<\/jats:italic>\u2009=\u20097). Copyright \u00a9 2014 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/bio.2639","type":"journal-article","created":{"date-parts":[[2014,3,3]],"date-time":"2014-03-03T06:51:47Z","timestamp":1393829507000},"page":"901-907","source":"Crossref","is-referenced-by-count":19,"title":["Chemiluminometric determination of ascorbic acid in pharmaceutical formulations exploiting photo\u2010activation of GSH\u2010capped CdTe quantum dots"],"prefix":"10.1002","volume":"29","author":[{"given":"M. K.","family":"Sasaki","sequence":"first","affiliation":[{"name":"NAPTISA\/Center for Nuclear Energy in Agriculture University of Sao Paulo  Piracicaba Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. S. M.","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"REQUIMTE\/Department of Chemical Sciences, Faculty of Pharmacy University of Porto  Porto Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Frigerio","sequence":"additional","affiliation":[{"name":"REQUIMTE\/Department of Chemical Sciences, Faculty of Pharmacy University of Porto  Porto Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. A. V.","family":"Prior","sequence":"additional","affiliation":[{"name":"REQUIMTE\/Department of Chemical Sciences, Faculty of Pharmacy University of Porto  Porto Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. L. M.","family":"Santos","sequence":"additional","affiliation":[{"name":"REQUIMTE\/Department of Chemical Sciences, Faculty of Pharmacy University of Porto  Porto Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. A. 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