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These quantum dots have advantages compared to traditional quantum dots with limited biological applications, high toxicity and tendency to aggregate. The concentration of Cu<jats:sup>2+<\/jats:sup> has a significant impact on the fluorescence intensity of quantum dots (QDs), therefore, a rapid sensitive and selective fluorescence probe has been proposed for the detection of Cu<jats:sup>2+<\/jats:sup> in aqueous solution. Under optimal conditions, the fluorescence intensity of CdTe\/ZnS QDs was linearly proportional to the concentration of Cu<jats:sup>2+<\/jats:sup> in the range from 2.5 \u00d7 10<jats:sup>\u20139<\/jats:sup> M to 17.5 \u00d7 10<jats:sup>\u20137<\/jats:sup> M with the limit of 1.5 \u00d7 10<jats:sup>\u20139<\/jats:sup> M and relative standard deviation of 0.23%. The quenching mechanism is static quenching with recoveries of 97.30\u2013102.75%. 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