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Separation of three local anaesthetics was achieved at 35\u2009\u00b0C on a C<jats:sub>18<\/jats:sub> column. The mobile phase was 30: 70 (v\/v) acetonitrile\/triethylamine\u2013phosphoric acid buffer (pH\u20092.9) at flow rate of 0.3\u2009mL\/min. The RRS detection was conducted by taking advantage of the strong RRS enhancement of the local anaesthetics with erythrosine reaction in an acidic medium. Under optimum conditions, the limit of detection (S\/N\u2009=\u20093) values were in the range of 2.4\u201311.2\u2009ng\/mL. Recoveries from spiked human urine samples were 95.8%\u2013104.5%. The proposed method applied to the determination of local anaesthetics in human urine achieved satisfactory results. In addition, the mechanism of the reaction is fully discussed. Copyright \u00a9 2016 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/bio.3140","type":"journal-article","created":{"date-parts":[[2016,5,5]],"date-time":"2016-05-05T02:46:45Z","timestamp":1462416405000},"page":"4-10","source":"Crossref","is-referenced-by-count":8,"title":["Resonance Rayleigh scattering technique as a detection method for the RP\u2010HPLC determination of local anaesthetics in human urine"],"prefix":"10.1002","volume":"32","author":[{"given":"Dan","family":"Liu","sequence":"first","affiliation":[{"name":"Education Ministry Key Laboratory on Luminescence and Real\u2010Time Analysis, Chemistry and Chemical Engineering Southwest University  Chongqing People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingdong","family":"Peng","sequence":"additional","affiliation":[{"name":"Education Ministry Key Laboratory on Luminescence and Real\u2010Time Analysis, Chemistry and Chemical Engineering Southwest University  Chongqing People's 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