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Upon delivery into a cell, in endocytic vesicles such as endosomes, their fluorescence is quenched. We have investigated the potential toxic effects, photophysical properties and cell internalization of QDs in new formulation of liposomes as an <jats:italic>in vitro<\/jats:italic> vesicle model. Entrapment of QDs into liposomes is brought about with a decrease in their intrinsic fluorescence and toxicities and an increase in their photostability and lifetime. The biomimetic lipid bilayer of liposomes provides high biocompatibility, thereby enhancing the effectiveness of fluorescent nanoparticles for biological recognition <jats:italic>in vitro<\/jats:italic> and <jats:italic>in vivo<\/jats:italic>. The prepared lipodots could effectively prevent QDs from photo\u2010oxidation during storage and when exposed to ultraviolet (UV) light. Moreover, the flow cytometry of HEK 293\u00a0T cells showed that the cell internalization of encapsulated QDs in (DSPC\/CHO\/DOPE\/DOAB) liposome is enhanced 10 times compared with non\u2010encapsulated QD (bare QDs).<\/jats:p>","DOI":"10.1002\/bio.3207","type":"journal-article","created":{"date-parts":[[2016,10,21]],"date-time":"2016-10-21T06:26:49Z","timestamp":1477031209000},"page":"517-528","source":"Crossref","is-referenced-by-count":19,"title":["Enhancement of cell internalization and photostability of red and green emitter quantum dots upon entrapment in novel cationic nanoliposomes"],"prefix":"10.1002","volume":"32","author":[{"given":"Hamid Reza","family":"Samadikhah","sequence":"first","affiliation":[{"name":"Department of Nanobiotechnology, Faculty of Biological Sciences Tarbiat Modares University  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Nikkhah","sequence":"additional","affiliation":[{"name":"Department of Nanobiotechnology, Faculty of Biological Sciences Tarbiat Modares University  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saman","family":"Hosseinkhani","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Biological Sciences Tarbiat Modares University  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,10,21]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.4847"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/jp971091y"},{"key":"e_1_2_8_4_1","volume-title":"Soft Chemical Synthesis and Manipulation of Semiconductor Nanocrystals","author":"Hollingsworth J. 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