{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T07:43:21Z","timestamp":1762674201826,"version":"build-2065373602"},"reference-count":42,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,9,14]],"date-time":"2017-09-14T00:00:00Z","timestamp":1505347200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004607","name":"Natural Science Foundation of Guangxi Province","doi-asserted-by":"publisher","award":["2015GXNSFAA139033","2016GXNSFBA380118"],"award-info":[{"award-number":["2015GXNSFAA139033","2016GXNSFBA380118"]}],"id":[{"id":"10.13039\/501100004607","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21225313","21403039","21473125","21563006"],"award-info":[{"award-number":["21225313","21403039","21473125","21563006"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Luminescence"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Ag<jats:sub>2<\/jats:sub>Te quantum dots (QDs) have attracted great attention in biological applications due to their superior photoluminescence qualities and good biocompatibility, but their potential biotoxicity at a molecular biology level has been rarely discussed. In order to better understand the basic behavior of Ag<jats:sub>2<\/jats:sub>Te QDs in biological systems and compare their biotoxicity to cadmium\u2010containing QDs, a series of spectroscopic measurements was applied to reveal the molecular interactions of Ag<jats:sub>2<\/jats:sub>Te QDs and CdTe QDs with human serum albumin (HSA). Ag<jats:sub>2<\/jats:sub>Te QDs and CdTe QDs statically quenched the intrinsic fluorescence of HSA by electrostatic interactions, but Ag<jats:sub>2<\/jats:sub>Te QDs exhibited weaker quenching ability and weaker binding ability compared with CdTe QDs. Electrostatic interactions were the main binding forces and Sudlow's site I was the primary binding site during these binding interactions. Furthermore, micro\u2010environmental and conformational variations of HSA were induced by their binding interactions with two QDs. Ag<jats:sub>2<\/jats:sub>Te QDs caused less secondary structural and conformational change in HSA, illustrating the lower potential biotoxicity risk of Ag<jats:sub>2<\/jats:sub>Te QDs. Our results systematically indicated the molecular binding mechanism of Ag<jats:sub>2<\/jats:sub>Te QDs with HSA, which provided important information for possible toxicity risk of these cadmium\u2010free QDs to human health.<\/jats:p>","DOI":"10.1002\/bio.3391","type":"journal-article","created":{"date-parts":[[2017,9,14]],"date-time":"2017-09-14T03:11:52Z","timestamp":1505358712000},"page":"181-189","source":"Crossref","is-referenced-by-count":11,"title":["Comparison of molecular interactions of Ag<sub>2<\/sub>Te and CdTe quantum dots with human serum albumin by spectroscopic approaches"],"prefix":"10.1002","volume":"33","author":[{"given":"Qi","family":"Xiao","sequence":"first","affiliation":[{"name":"College of Chemistry and Materials Science Guangxi Teachers Education University  Nanning People's Republic of China"},{"name":"State Key Laboratory of Virology, College of Chemistry and Molecular Sciences Wuhan University  Wuhan People's Republic of 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