{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:32:29Z","timestamp":1786977149768,"version":"build-2736575974"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,1,19]],"date-time":"2020-01-19T00:00:00Z","timestamp":1579392000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Luminescence"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Losartan potassium (LOS) and atorvastatin (ATR) are used in combination for long\u2010term treatment of stroke and for treatment of hypertension with high\u2010level cholesterol. Both drugs were simultaneously determined and validated using a novel, easy, fast, and economical first\u2010derivative synchronous fluorescence spectroscopic method. Methanol was used as the solvent for both drugs at a \u0394\u03bb 80 nm and with a scanning rate of 600 nm\/min. Peaks were determined as at 288.1 nm and 263.6 nm for LOS and ATR, respectively. The proposed method was validated according to International Conference on Harmonization guidelines and, subsequently, the developed method was applicable to the analysis of the two compounds in their different formulations without interference from each other. Amplitude\u2013concentration plots were rectilinear over the concentration ranges 1.0\u201310.0 \u03bcg\/ml and 0.5\u20135.0 \u03bcg\/ml for LOS and ATR, respectively. Detection limits were found to be 0.096 \u03bcg\/ml and 0.030 \u03bcg\/ml and quantitation limits were 0.291 \u03bcg\/ml and 0.093 \u03bcg\/ml for LOS and ATR, respectively. The proposed method was successfully applied to the analysis of both compounds in synthetic mixtures and in laboratory\u2010prepared tablets. These results were in accordance with the results acquired using the comparison method, high\u2010performance liquid chromatography.<\/jats:p>","DOI":"10.1002\/bio.3755","type":"journal-article","created":{"date-parts":[[2020,1,19]],"date-time":"2020-01-19T20:25:21Z","timestamp":1579465521000},"page":"561-571","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["First\u2010derivative synchronous spectrofluorimetric method for estimation of losartan potassium and atorvastatin in their pure forms and in tablets"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3325-1343","authenticated-orcid":false,"given":"Norhane","family":"Attaa Bakr","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy Mansoura University  Mansoura Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samar","family":"Saad","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy Mansoura University  Mansoura Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasser","family":"Elshabrawy","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy Mansoura University  Mansoura Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manal","family":"Eid","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy Mansoura University  Mansoura Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,1,19]]},"reference":[{"key":"e_1_2_5_2_1","volume-title":"The methods of fluorescence analysis","author":"Chen G.\u2010Z.","year":"1990"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.saa.2018.06.102"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsos.181359"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/bio.2852"},{"key":"e_1_2_5_6_1","unstructured":"The United States Pharmacopeia 2011: USP 34; The national formulary: NF 29 United States Pharmacopeial Convention Rockville MD 2010."},{"key":"e_1_2_5_7_1","volume-title":"Martindale","author":"Sweetman S. 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