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The main principle used in the proposed approach was the condensation reaction between heptaminol's primary amino moiety and ethyl acetoacetate\/formaldehyde reagents, giving a derivative that was highly fluorescent at 416 nm after excitation at 350 nm. Various experimental parameters that affected either the product's development or its stability were evaluated and optimized. The constructed calibration curve was linear over the range 0.2\u20132 \u03bcg\/ml, with a good correlation coefficient (0.9996). Both the calculated limit of detection and limit of quantitation were 0.06 and 0.18 \u03bcg\/ml, respectively. The presented approach was a success when used to determine Corasore\u00ae tablets and was validated according to International Council for Harmonisation guidelines.<\/jats:p>","DOI":"10.1002\/bio.3787","type":"journal-article","created":{"date-parts":[[2020,1,28]],"date-time":"2020-01-28T22:45:35Z","timestamp":1580251535000},"page":"821-826","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Condensation of heptaminol hydrochloride for its spectrofluorimetric determination in pure form and tablets: application in human plasma"],"prefix":"10.1002","volume":"35","author":[{"given":"Monica E.","family":"Halim","sequence":"first","affiliation":[{"name":"Analytical Chemistry Department, Faculty of Pharmacy Minia University  Minia Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6635-7606","authenticated-orcid":false,"given":"Mahmoud A.","family":"Omar","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy and Pharmaceutical Chemistry, College of Pharmacy Taibah University  Medinah Saudi Arabia"},{"name":"Pharmaceutical Chemistry Department, Faculty of Pharmacy Minia University  Minia Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dalia M.","family":"Nagy","sequence":"additional","affiliation":[{"name":"Analytical Chemistry Department, Faculty of Pharmacy Minia University  Minia Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,1,28]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1962.tb01149.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.farmac.2004.03.013"},{"key":"e_1_2_5_4_1","first-page":"139","volume":"57","author":"Salman S.","year":"1989","journal-title":"Sci. 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