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The procedure was dependent on oxidation of the investigated phenothiazines using a known excess of ammonium cerium sulfate as oxidizing agent and overseeing the fluorescence intensity of the resultant Ce<jats:sup>3+<\/jats:sup>ion as the product of this reaction at \u03bb<jats:sub>cx<\/jats:sub> = 254 nm. and \u03bb<jats:sub>em<\/jats:sub> = 355 nm. Various parameters controlling the reaction were investigated and optimized. Linear calibration graphs were found in the general concentration range 5\u201330 ng\/ml with a general correlation coefficient range 0.9994\u20130.9995. Limits of detection were 0.97, 0.70 and 0.56 ng\/ml, whereas limits of quantification were 3.24, 2.12 and 1.89 ng\/ml for trifluoperazine hydrochloride, promethazine hydrochloride and perazine maleate, respectively. The procedure was implemented successfully for analyses of the cited drugs in their trade dosage preparations such as tablets and syrups. The effect of possible interference from common excipients and their sulfoxide oxidized product was studied and the procedure showed good recovery of the drugs under study in their available dosage preparations. The possible effect of structure variation of the studied drugs on the experimental conditions and sensitivity observed with each one was also discussed.<\/jats:p>","DOI":"10.1002\/bio.3826","type":"journal-article","created":{"date-parts":[[2020,7,22]],"date-time":"2020-07-22T02:00:53Z","timestamp":1595383253000},"page":"1134-1141","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Highly sensitive spectrofluorimetric procedure for the assay of phenothiazine derivatives in the presence of their sulfoxide oxidized product"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6635-7606","authenticated-orcid":false,"given":"Mahmoud A.","family":"Omar","sequence":"first","affiliation":[{"name":"Department of Pharmacognosy and Pharmaceutical Chemistry, College of Pharmacy Taibah University  Medinah Saudi Arabia"},{"name":"Analytical Chemistry Department, Faculty of Pharmacy Minia University  Minia Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdel\u2010Maaboud","family":"Mohamed","sequence":"additional","affiliation":[{"name":"Pharmaceutical Chemistry Department, Faculty of Pharmacy Assiut University  Assiut Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dalia M.","family":"Nagy","sequence":"additional","affiliation":[{"name":"Analytical Chemistry Department, Faculty of Pharmacy Minia University  Minia Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hesham","family":"Salem","sequence":"additional","affiliation":[{"name":"Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy Deraya University  Minia Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4148-5388","authenticated-orcid":false,"given":"Osama H.","family":"Abdelmageed","sequence":"additional","affiliation":[{"name":"Pharmaceutical Chemistry Department, Faculty of Pharmacy King Abdulaziz University  Jeddah Kingdom of Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,7,21]]},"reference":[{"key":"e_1_2_5_2_1","volume-title":"Clarke's Analysis of Drugs and Poisons","author":"Moffat A. 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