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Hydrogen sulfide (H<jats:sub>2<\/jats:sub>S), as a double\u2010edged sword, plays an important role in biological systems. Studies have revealed that endogenous H<jats:sub>2<\/jats:sub>S is important to maintain normal physiological functions. Conversely, abnormal levels of H<jats:sub>2<\/jats:sub>S may contribute to various diseases. Due to the importance of H<jats:sub>2<\/jats:sub>S in physiology and pathology, research into the effects of H<jats:sub>2<\/jats:sub>S has been active in recent years. Fluorescent probes with red\/near\u2010infrared (NIR) emissions (620\u2013900 nm) are more suitable for imaging applications <jats:italic>in vivo<\/jats:italic>, because of their negligible photodamage, deep tissue penetration, and maximum lack of interference from background autofluorescence. H<jats:sub>2<\/jats:sub>S, an \u2018evil and positive\u2019 molecule, is not only toxic, but also produces significant effects; a \u2018greedy\u2019 molecule, is not only a strong nucleophile under physiological conditions, but also undergoes a continuous double nucleophilic reaction. Therefore, in this tutorial review, we will highlight recent advances made since 2015 in the development and application of red\/NIR fluorescent probes based on nucleophilic reactions of H<jats:sub>2<\/jats:sub>S.<\/jats:p>","DOI":"10.1002\/bio.3831","type":"journal-article","created":{"date-parts":[[2020,9,21]],"date-time":"2020-09-21T07:08:48Z","timestamp":1600672128000},"page":"1156-1173","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["A review: Red\/near\u2010infrared (NIR) fluorescent probes based on nucleophilic reactions of H<sub>2<\/sub>S since 2015"],"prefix":"10.1002","volume":"35","author":[{"given":"JunPing","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Chemistry Xinzhou Teachers University  Xinzhou Shanxi China"},{"name":"Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Institute of Molecular Science Shanxi University  Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangjun","family":"Huo","sequence":"additional","affiliation":[{"name":"Research Institute of Applied Chemistry Shanxi University  Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongkang","family":"Yue","sequence":"additional","affiliation":[{"name":"Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Institute of Molecular Science Shanxi University  Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5548-6333","authenticated-orcid":false,"given":"Caixia","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Chemistry Xinzhou Teachers University  Xinzhou Shanxi China"},{"name":"Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Institute of Molecular Science Shanxi University  Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,9,21]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2017.11.011"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2017.07.003"},{"key":"e_1_2_7_4_1","doi-asserted-by":"crossref","unstructured":"G. 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