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The formed fluorescent product was measured at an emission wavelength of 479 nm after excitation at 419 nm. Parameters that influenced the reaction were studied and adjusted accurately. The constructed calibration graph was rectilinear over the range 200\u20132000 ng ml<jats:sup>\u22121<\/jats:sup> and the estimated limit of detection was 60 ng ml<jats:sup>\u22121<\/jats:sup>. Two products from an Egyptian market were assayed using the suggested method and the final results agreed with the measurements of the reported method. The selectivity of the proposed approach was evaluated using the standard addition method and results were acceptable and confirmed the reliability of this approach. Finally, directives from the International Council for Harmonisation guidelines were applied to establish the validity of the study.<\/jats:p>","DOI":"10.1002\/bio.3898","type":"journal-article","created":{"date-parts":[[2020,6,10]],"date-time":"2020-06-10T04:39:11Z","timestamp":1591763951000},"page":"1360-1365","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Use of acetylacetone for nano\u2010level assay of fluvoxamine maleate in pure form and pharmaceutical formulation"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5016-1916","authenticated-orcid":false,"given":"Ahmed A.","family":"Abu\u2010hassan","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy Al\u2010Azhar University, Assiut branch  Assiut Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahmoud A.","family":"Omar","sequence":"additional","affiliation":[{"name":"Pharmacognosy and Pharmaceutical Chemistry Department, College of Pharmacy Taibah University  Medinah Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sayed M.","family":"Derayea","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry, Faculty of Pharmacy Minia University  Minia Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,6,23]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"611","volume":"22","author":"Blackwell B.","year":"1986","journal-title":"Drugs Today"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-198632040-00002"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0731-7085(00)00296-X"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.saa.2008.12.009"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0731-7085(00)00323-X"},{"key":"e_1_2_5_7_1","first-page":"245","volume":"58","author":"Starczewska B.","year":"2003","journal-title":"Pharmazie"},{"key":"e_1_2_5_8_1","first-page":"450","volume":"4","author":"Kishore M.","year":"2011","journal-title":"RJPT."},{"key":"e_1_2_5_9_1","first-page":"6373","volume":"3","author":"Revathi S.","year":"2013","journal-title":"Indo Am. 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