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Fluorescence quantum yield of the probe clearly increased when using triphenylamine\u2013benzothiazole as the group. The probe possessed good selectivity towards CN<jats:sup>\u2212<\/jats:sup> and had anti\u2010interference ability over common ions. After adding CN<jats:sup>\u2212<\/jats:sup>, the UV\u2013visible spectrum of TBI changed clearly and underwent a dramatic colour change from red to colourless, which could be observed clearly by the naked eye. The limit of detection for CN<jats:sup>\u2212<\/jats:sup> was calculated to be 2.62 \u00d7 10<jats:sup>\u22128<\/jats:sup> M, which was well below the WHO cut\u2010off point of 1.9 \u03bcM. The novel probe displayed fast sensing of CN<jats:sup>\u2212<\/jats:sup>. The detection mechanism was a nucleophilic addition reaction between CN<jats:sup>\u2212<\/jats:sup> and a carbon atom \u2013C = N\u2013 in indole salt. The \u03c0\u2010conjugation and intramolecular charge transfer (ICT) transition in the TBI molecule were destroyed by this addition, which resulted in a change of fluorescence before and after the addition of CN<jats:sup>\u2212<\/jats:sup>. The mechanism was verified using theoretical calculation, <jats:sup>1<\/jats:sup>H NMR titration, and mass spectra. In addition, the probe showed low cytotoxicity and could be used for biological imaging in HeLa cells.<\/jats:p>","DOI":"10.1002\/bio.3946","type":"journal-article","created":{"date-parts":[[2020,9,27]],"date-time":"2020-09-27T02:46:11Z","timestamp":1601174771000},"page":"336-344","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["A new highly selective fluorescent sensor based on a novel fluorophore for cyanide and its applications in bioimaging"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5391-3327","authenticated-orcid":false,"given":"Yan","family":"Liu","sequence":"first","affiliation":[{"name":"College of Chemistry Jilin University  Changchun China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian shi","family":"Du","sequence":"additional","affiliation":[{"name":"Key Laboratory of Lymphatic Surgery Jilin Province China\u2013Japan Union Hospital of 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