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Dipodand <jats:bold>3<\/jats:bold> and tetrapodand <jats:bold>4<\/jats:bold> showed a switching \u2018ON\u2019 of fluorescence (\u03bb<jats:sub>em<\/jats:sub> = 435\u2013445) with Zn<jats:sup>2+<\/jats:sup> and Cd<jats:sup>2+<\/jats:sup> (OR logic) and switching \u2018OFF\u2019 of fluorescence (\u03bb<jats:sub>em<\/jats:sub> = 402) in the presence of Cu<jats:sup>2+<\/jats:sup>, Co<jats:sup>2+<\/jats:sup> and Ni<jats:sup>2+<\/jats:sup> (NOR logic). <jats:bold>4<\/jats:bold> showed switching \u2018OFF\u2019 of fluorescence at 402 nm at low concentrations of Ag<jats:sup>+<\/jats:sup>, Pb<jats:sup>2+<\/jats:sup>, Hg<jats:sup>2+<\/jats:sup> and Fe<jats:sup>3+<\/jats:sup> and, on further accumulation of these metal ions, excimer bands at 432 nm (Ag<jats:sup>+<\/jats:sup>) and 510 nm (Pb<jats:sup>2+<\/jats:sup>, Hg<jats:sup>2+<\/jats:sup> and Fe<jats:sup>3+<\/jats:sup>) provided the opportunity for \u2018ON\u2013OFF\u2013ON\u2019 switching. In contrast, <jats:bold>3<\/jats:bold> showed no change with Ag<jats:sup>+<\/jats:sup>, while Pb<jats:sup>2+<\/jats:sup> caused only \u2018ON\u2013OFF\u2019 switching and Hg<jats:sup>2+<\/jats:sup> and Fe<jats:sup>3+<\/jats:sup> ions caused similar \u2018ON\u2013OFF\u2013ON\u2019 switching. The H<jats:sup>+<\/jats:sup>\u2010induced \u2018ON\u2013OFF\u2013ON\u2019 molecular switch was combined with Cu<jats:sup>2+<\/jats:sup> that persuaded NOR logic to mimic inhibit (INH) logic. The compound also exhibited a H<jats:sup>+<\/jats:sup>\/Cu<jats:sup>2+<\/jats:sup>\u2010induced \u2018OFF\u2013ON\u2013OFF\u2019 type of signalling pattern. These proton\u2010induced multiple outputs provide opportunities for YES, NOT logic gates. <jats:bold>3<\/jats:bold> showed selective \u2018ON\u2013OFF\u2019 behaviour with Fe<jats:sup>3+<\/jats:sup> ions and \u2018OFF\u2013ON\u2019 behaviour with Cd<jats:sup>2+<\/jats:sup> ions in 20% HEPES buffer\u2013CH<jats:sub>3<\/jats:sub>CN.<\/jats:p>","DOI":"10.1002\/bio.4005","type":"journal-article","created":{"date-parts":[[2021,1,2]],"date-time":"2021-01-02T05:01:18Z","timestamp":1609563678000},"page":"802-811","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Molecular switches and dual channel detection of Cd<sup>2+<\/sup> and Fe<sup>3+<\/sup> ions based on a multipodand system"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0542-6513","authenticated-orcid":false,"given":"Prabhpreet","family":"Singh","sequence":"first","affiliation":[{"name":"Department of Chemistry, UGC Centre for Advanced Studies\u2212II Guru Nanak Dev University  Amritsar India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,1,28]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja00322a055"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja00013a096"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/43646"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1351\/pac200375101383"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.5b00146"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8CS00888D"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.8b00296"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7CS00068E"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7CS00245A"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscentsci.9b01185"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.9b08761"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja00444a046"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr00003a007"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201602594"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.8b09843"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.9b00291"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.9b00221"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.9b00159"},{"key":"e_1_2_6_20_1","first-page":"46","volume":"2017","author":"Lewis J. 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