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However, the action mechanism of resorcinol and human DNA has not been elucidated. In this research, the binding properties between resorcinol and calf thymus DNA (ct\u2010DNA) were studied for the first time through various spectral and molecular docking techniques. Spectral studies showed that the initial fluorescence quenching of resorcinol against DNA was a static one. The result of \u0394H\u2009&lt;\u20090 and \u0394S\u2009&gt;\u20090 was produced from thermodynamic experimental data, therefore it could be concluded that electrostatic force was the major driving force, while binding constant K<jats:sub>b<\/jats:sub> was 1.56\u2009\u00d7\u200910<jats:sup>4<\/jats:sup>\u2009M<jats:sup>\u22121<\/jats:sup> at 298\u2009K. The electrostatic binding network between resorcinol and ct\u2010DNA was established explicitly through competitive substitution analysis and other spectral approaches. The results of FT\u2010IR absorption spectra indicated that resorcinol had bound to the DNA phosphate skeleton. Molecular docking clearly revealed that binding occurred between hydroxyl groups of resorcinol and phosphorus oxygen bonds (P\u2013O) of the DNA skeleton. These findings may deepen our understanding of the action mechanism between resorcinol and ct\u2010DNA and provide some useful data on the effect of resorcinol on human diseases.<\/jats:p>","DOI":"10.1002\/bio.4140","type":"journal-article","created":{"date-parts":[[2021,9,9]],"date-time":"2021-09-09T05:05:13Z","timestamp":1631163913000},"page":"4-13","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Revealing the binding properties between resorcinol and DNA"],"prefix":"10.1002","volume":"37","author":[{"given":"Guofang","family":"Zeng","sequence":"first","affiliation":[{"name":"College of Chemistry Nanchang University  Nanchang Jiangxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fengping","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Pharmacy Nanchang University  Nanchang Jiangxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yating","family":"Lei","sequence":"additional","affiliation":[{"name":"School of Pharmacy Nanchang University  Nanchang Jiangxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Like","family":"Zhou","sequence":"additional","affiliation":[{"name":"College of Chemistry Nanchang University  Nanchang Jiangxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xi","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Pharmacy Nanchang University  Nanchang Jiangxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Guo","sequence":"additional","affiliation":[{"name":"College of Chemistry Nanchang University  Nanchang Jiangxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5766-763X","authenticated-orcid":false,"given":"Xun","family":"Tuo","sequence":"additional","affiliation":[{"name":"College of Chemistry Nanchang University  Nanchang Jiangxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Guo","sequence":"additional","affiliation":[{"name":"College of Chemistry Nanchang University  Nanchang Jiangxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,9,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24091744"},{"key":"e_1_2_7_3_1","first-page":"1","volume":"67","author":"Zhang G.","year":"2016","journal-title":"J. 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