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The drug was mixed with the reagent in the presence of 2\u2010mercaptoethanol and the reaction was carried out in slightly alkaline aqueous solution containing 0.1\u2009M sodium hydroxide. The resulting product exhibited high fluorescence activity that was measured at 451\u2009nm after excitation at 334\u2009nm. The linearity range of the method was 5\u2013100\u2009ng\u2009ml<jats:sup>\u22121<\/jats:sup> with a lower detection limit of 1.8\u2009ng\u2009ml<jats:sup>\u22121<\/jats:sup>. The procedure was evaluated according to the International Council of Harmonization guidelines. The proposed method was applied to analyze the drug in pharmaceutical tablets and oral drops. In addition, the present study represents the first spectrofluorimetric method for the determination of the cited drug in real human plasma. The method provided high recovery percentages without any interference from coexisting pharmaceutical excipients or the components of human plasma.<\/jats:p>","DOI":"10.1002\/bio.4164","type":"journal-article","created":{"date-parts":[[2021,11,18]],"date-time":"2021-11-18T02:25:25Z","timestamp":1637202325000},"page":"230-237","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Orthophthaldehyde as a fluorescent probe for the feasible and sensitive assay of heptaminol: application to dosage forms and real human plasma"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5357-1761","authenticated-orcid":false,"given":"Sayed M.","family":"Derayea","sequence":"first","affiliation":[{"name":"Analytical Chemistry Department, Faculty of Pharmacy Minia University  Minia Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pakinaz Y.","family":"Khashaba","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Analytical Chemistry Assiut University, Faculty of Pharmacy  Assiut Egypt"},{"name":"Department of Pharmaceutical Analytical Chemistry Sphinx University, Faculty of Pharmacy  New Assiut City Assiut Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud","family":"Abdelgaleel","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Analytical Chemistry Deraya University, Faculty of Pharmacy  New Mina City Minia Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dalia M.","family":"Nagy","sequence":"additional","affiliation":[{"name":"Analytical Chemistry Department, Faculty of Pharmacy Minia University  Minia Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,11,26]]},"reference":[{"key":"e_1_2_8_2_1","volume-title":"Martindale: The Complete Drug Reference","author":"Sweetman S. 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